PMID: 8583243Oct 1, 1995Paper

Expression of the human Achaete-scute 1 gene in olfactory neuroblastoma (esthesioneuroblastoma)

Journal of Neuro-oncology
M E CarneyJ L Rothstein

Abstract

Olfactory neuroblastoma (ONB) is a rare neuronal malignancy of the olfactory mucosal. Markers used in the diagnosis of ONB do not distinguish ONB from other neuronal tumors or tumors with neuroendocrine features thus making the diagnosis of ONB difficult. Using a modified RT-PCR technique, we show that the human homologue of the Drosophila achaete-scute gene HASH1 is expressed in 6 primary and one metastatic ONB specimens, whereas Olfactory Marker Protein (OMP) is not. Previous studies have shown that HASH1 is expressed in immature olfactory neurons and is required for their development. OMP, whose function is unknown, is expressed exclusively in mature olfactory neurons. Together, these data suggest that ONB is derived from immature olfactory neurons of neuroectodermal origin. Analysis of RNA expression in primary tumor specimens and in an established cell line make this an ideal system to study olfactory growth and differentiation. Furthermore, these studies represent the first molecular genetic analysis of this rare and unusual neuronal tumor.

References

Nov 1, 1977·The Annals of Otology, Rhinology, and Laryngology·R W CantrellG S Fitz-Hugh
Jul 1, 1992·Genes & Development·J L RothsteinB Knowles
Jan 15, 1991·Biochemical and Biophysical Research Communications·F von WeizsäckerH E Blum
Jan 1, 1991·The American Journal of Pediatric Hematology/oncology·V L CastañedaR T Parmley
Apr 1, 1990·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P KotilainenP Huovinen
Jun 15, 1989·Cancer·T A O'ConnorR G Parker
Feb 1, 1986·Molecular and Cellular Biology·P I PatelA C Chinault
Nov 1, 1987·Cancer Genetics and Cytogenetics·J Whang-PengA Gazdar
Jan 1, 1985·Journal of Neuropathology and Experimental Neurology·H S Choi, P J Anderson
Jul 15, 1982·The New England Journal of Medicine·J Q TrojanowskiS Lee
May 11, 1981·Brain Research·F Galan GalanI MacIntyre
Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D W BallB D Nelkin

❮ Previous
Next ❯

Citations

Dec 9, 2000·Biochemical and Biophysical Research Communications·K NibuJ L Rothstein
Feb 3, 2007·Skull Base : Official Journal of North American Skull Base Society ... [et Al.]·Prakash SampathPrakash Chougule
Mar 21, 2002·The Lancet Oncology·P DulguerovT C Calcaterra
Sep 15, 2014·Surgical and Radiologic Anatomy : SRA·Roger JankowskiDuc Trung Nguyen
Nov 18, 2008·Hematology/oncology Clinics of North America·Danny Rischin, Andrew Coleman
Sep 30, 2003·Current Opinion in Otolaryngology & Head and Neck Surgery·Patrick J BradleyIain Robertson
Jul 28, 2011·The Laryngoscope·Eric H HolbrookJames E Schwob
Nov 15, 2011·Otolaryngologia polska. The Polish otolaryngology·Ewa MajchrzakWojciech Golusiński
Jul 7, 2020·The Annals of Otology, Rhinology, and Laryngology·Gregory L BarinskyJean Anderson Eloy
May 8, 2018·Acta Neuropathologica·David CapperUlrich Schüller
Mar 19, 1999·Biochemical and Biophysical Research Communications·H SöderholmS Påhlman
Sep 9, 2020·Bulletin du cancer·Benoit DumontDaniel Orbach

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.