Expression of the hyaluronan-mediated motility receptor RHAMM in tumor budding cells identifies aggressive colorectal cancers

Human Pathology
Viktor H KoelzerAlessandro Lugli

Abstract

Expression of the hyaluronan-mediated motility receptor (RHAMM, CD168) predicts adverse clinicopathological features and decreased survival for colorectal cancer (CRC) patients. Using full tissue sections, we investigated the expression of RHAMM in tumor budding cells of 103 primary CRCs to characterize the biological processes driving single-cell invasion and early metastatic dissemination. RHAMM expression in tumor buds was analyzed with clinicopathological data, molecular features and survival. Tumor budding cells at the invasive front of CRC expressed RHAMM in 68% of cases. Detection of RHAMM-positive tumor budding cells was significantly associated with poor survival outcome (P = .0312), independent of TNM stage and adjuvant therapy in multivariate analysis (P = .0201). RHAMM-positive tumor buds were associated with frequent lymphatic invasion (P = .0007), higher tumor grade (P = .0296), and nodal metastasis (P = .0364). Importantly, the prognostic impact of RHAMM expression in tumor buds was maintained independently of the number of tumor buds found in an individual case (P = .0246). No impact of KRAS/BRAF mutation, mismatch repair deficiency and CpG island methylation was observed. RHAMM expression identifies an aggressi...Continue Reading

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Citations

Apr 22, 2017·Oncotarget·Mengyuan LiXiaosheng Wang
Sep 29, 2017·Journal of Ovarian Research·Stephanie T ButtermorePatricia A Kruk
Feb 26, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Huizhong ZhangDongsheng Zhang
Aug 17, 2019·Frontiers in Oncology·Ru He, Shuguang Zuo
May 20, 2016·Cancer Research·Eva A TurleyJames B McCarthy
Apr 18, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Martin WartenbergEva Karamitopoulou
Nov 28, 2020·Colloids and Surfaces. B, Biointerfaces·Hualu LaiShengmiao Cui
Feb 4, 2021·Bioengineering & Translational Medicine·Daniel C PanSamir Mitragotri
Jun 9, 2021·Biomolecules & Therapeutics·You SunKyung Song

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