Expression of the IFNAR1 chain of type 1 interferon receptor in benign cells protects against progression of acute leukemia

Leukemia & Lymphoma
Bin ZhaoSerge Y Fuchs

Abstract

Type I interferons (IFN) were widely used for leukemia treatment. These cytokines act on cell surface receptor consisting of the IFNAR1/2 chains to induce anti-tumorigenic effects. Given that levels of IFNAR1 can be regulated by phosphorylation-driven ubiquitination and degradation that undermines IFN signaling and anti-tumorigenic effects, we sought to determine the importance of IFNAR1 downregulation in progression of acute leukemia. Using knock-in mice deficient in downregulation of IFNAR1, we uncovered that IFNAR1 expression in stromal benign cells functions to protect against progression of leukemia. We discuss putative mechanisms of this regulation and potential of therapeutic targeting of IFNAR1 downregulation to treat leukemia.

References

May 3, 2005·Nature Reviews. Immunology·Leonidas C Platanias
Dec 27, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Efstratios KatsoulidisLeonidas C Platanias
Aug 21, 2007·Cytokine & Growth Factor Reviews·Lisa A Kujawski, Moshe Talpaz
Jan 2, 2008·Biochemical and Biophysical Research Communications·Jianghuai LiuSerge Y Fuchs
Dec 2, 2009·The Journal of Biological Chemistry·Sabyasachi BhattacharyaSerge Y Fuchs
Dec 4, 2010·Genes & Cancer·Wei-Chun Huangfu, Serge Y Fuchs
Dec 22, 2010·Molecular and Cellular Biology·Hui ZhengSerge Fuchs
Apr 11, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Serge Y Fuchs
Jun 5, 2013·Oncoimmunology·Evelien L J M SmitsZwi N Berneman
Jan 28, 2014·Nature Biotechnology·Shawn T BeugRobert G Korneluk
Feb 1, 2014·EMBO Molecular Medicine·Sabyasachi BhattacharyaSerge Y Fuchs
Mar 13, 2014·The Journal of Experimental Medicine·Marcus JäråsBenjamin L Ebert
Sep 14, 2014·Molecular Cancer Research : MCR·Eleanor N Fish, Leonidas C Platanias
Sep 23, 2014·Cancer Cell·Rebekka K SchneiderBenjamin L Ebert
Mar 31, 2015·Annals of Hematology·Moshe TalpazRüdiger Hehlmann
Jun 2, 2015·Nature Reviews. Immunology·Laurence ZitvogelGuido Kroemer
Jan 27, 2016·Molecular and Cellular Biology·Yuliya V KatlinskayaSerge Y Fuchs
Feb 10, 2016·Cancer Cell·Najoua LalaouiJohn Silke
Feb 26, 2016·Nature Reviews. Cancer·Belinda S ParkerPaul J Hertzog
Mar 1, 2016·Virusdisease·Nilotpal Banerjee, Sumi Mukhopadhyay
Feb 4, 2010·Pharmaceuticals·Efstratios KatsoulidisLeonidas C Platanias

❮ Previous
Next ❯

Citations

Mar 25, 2019·Molecular Cancer Research : MCR·Jun GuiSerge Y Fuchs

❮ Previous
Next ❯

Related Concepts

Related Feeds

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.