PMID: 8454258Feb 1, 1993Paper

Expression of the Ig-associated heterodimer (mb-1 and B29) in Hodgkin's disease

Histopathology
I KuzuDavid Y Mason

Abstract

Eighty-three cases of Hodgkin's disease were studied immunocytochemically for the presence of the Ig associated heterodimer (mb-1 and B29) which is believed to be a specific pan B-cell marker. These results were compared with those achieved using other B-cell markers against CD19, CD20 and CD22. Although a small number of cases of nodular sclerosis and mixed cellularity subtype showed positivity for CD19, CD20 or CD22, no case showed any reactivity with antibodies against mb-1 or B29. This contrasted markedly with the cases of lymphocyte predominance where all seven cases expressed one or more of the B-cell antigens, with six cases being positive for mb-1. These results confirm previous studies that have suggested lymphocyte-predominance Hodgkin's disease is of B-cell origin and different from the other subtypes. However, they do not provide support for the thesis that these other subtypes may also have a B-cell origin, albeit with a different phenotype to lymphocyte predominance.

References

Oct 1, 1992·European Journal of Immunology·D Y MasonJ J van Dongen
Jun 1, 1991·Immunology Today·J E Alés-MartínezD W Scott
Jun 1, 1991·Immunology Today·M RethJ C Cambier
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G G HermansonR Wall
Dec 1, 1989·Histopathology·M L CibullD Y Mason
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G G HermansonR Wall
Feb 1, 1984·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J L CordellD Y Mason

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Citations

Aug 14, 1997·The New England Journal of Medicine·T OhnoW C Chan
Jun 6, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Jennifer C PatersonTeresa Marafioti
Aug 10, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A F LauritzenE Ralfkiaer
Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·A BraeuningerM L Hansmann
Jun 9, 2001·Applied Immunohistochemistry & Molecular Morphology : AIMM·P G Chu, D A Arber
Dec 1, 1995·Leukemia & Lymphoma·C S PapadimitriouP Hytiroglou
Nov 13, 2004·The Journal of Pathology·Eva-Maria SchneiderBernd Giebel
Sep 1, 1996·Baillière's Clinical Haematology·H J Gruss, M E Kadin
Aug 1, 2006·The American Journal of Pathology·Christoph RennéAndreas Bräuninger
Mar 12, 2004·Critical Reviews in Oncology/hematology·Alessandro MorabitoGiampietro Gasparini
Jun 1, 1994·Histopathology·P KorkolopoulouD Y Mason
Oct 13, 2020·The Journal of Pathology·Sibrandes Poppema

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