Expression of the innate immune receptor LILRB5 on monocytes is associated with mycobacteria exposure

Scientific Reports
Louise E HoganRachel L Allen

Abstract

Antigen presenting cells (APC) are critical components of innate immunity and consequently shape the adaptive response. Leukocyte Ig Like Receptors (LILR) are innate immune receptors predominantly expressed on myeloid cells. LILR can influence the antigen presenting phenotype of monocytic cells to determine the nature of T cell responses in infections including Mycobaterium leprae. We therefore investigated the relevance of LILR in the context of Mycobacterium tuberculosis. Real-time PCR studies indicated that the transcriptional profile of the orphan receptor LILRB5 was significantly up-regulated following exposure to mycobacteria. Furthermore, LILRA1 and LILRB5 were able to trigger signalling through direct engagement of mycobacteria using tranfectant cells incorporating a reporter system. We describe for the first time the expression of this receptor on T cells, and highlight the potential relevance to mycobacterial recognition. Furthermore, we demonstrate that crosslinking of this receptor on T cells increases proliferation of cytotoxic, but not helper, T cells.

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Citations

May 17, 2019·Nature Reviews. Rheumatology·Robert BuschElizabeth D Mellins
Jan 10, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuxi ZhaoAlex J McCarthy
Jun 30, 2019·The Journal of Infectious Diseases·Siqi MingXi Huang
Jun 2, 2020·Frontiers in Immunology·Alexander L Lewis Marffy, Alex J McCarthy
Nov 18, 2020·Molecular Therapy. Methods & Clinical Development·Narjes Saheb Sharif-AskariRabih Halwani
May 1, 2021·Antibody Therapeutics·Mi DengCheng Cheng Zhang

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Datasets Mentioned

BETA
GM-CSF

Methods Mentioned

BETA
PCR
flow cytometry
transfection

Software Mentioned

Stratagene MxPro
Weasel
FACS Diva
FlowJo VX
CFX manager
qBasePLUS
GraphPad Prism
SPSS

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