PMID: 9555577Apr 29, 1998Paper

Expression of the insulin-like growth factor system in postpneumonectomy lung growth

Experimental Lung Research
W A PriceA D Stiles

Abstract

The insulin-like growth factors (IGF-I and IGF-II) may play an important role in postpneumonectomy compensatory lung growth by translating hormonal inputs and mechanical forces into cellular proliferation signals. We examined the mRNA abundance of IGF-I, IGF-II, and IGF binding proteins (IGFBPs) in lungs of rats on postoperative days 1, 2, 3, 5, and 7 following left pneumonectomy (PNX) or shamoperation (SC) and in normal animals (CON). There was no difference in the abundance of lung IGF-I mRNA (measured by Northern analysis) or serum IGF-I (measured by radioimmunoassay (RIA)) between SC and PNX animals. IGF-II mRNA abundance was initially decreased following PNX (73% decrease compared to SC animals on day 1, p < .05) and then rose to approach SC group values on subsequent days. Transcripts for IGFBP-2, -3, -4, -5, and -6 were decreased in both the SC and PNX groups compared to CON animals on the day following pneumonectomy, then rose back to baseline by postoperative day 2-3. Tissue IGFBPs, measured by ligand blot analyses, were not different in either the SC or PNX groups. In contrast, all serum IGFBP bands were increased on postoperative day 1 following either sham or PNX surgery. In addition, serum IGFBP-4 was increased in ...Continue Reading

References

Jun 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A GhaharyL J Murphy
Nov 1, 1992·Scandinavian Journal of Clinical and Laboratory Investigation·S KuboiK Kida
May 1, 1992·Experimental Lung Research·M H KhadempourW M Thurlbeck
Sep 1, 1990·American Journal of Respiratory Cell and Molecular Biology·G Z Retsch-BogartA J D'Ercole
Jul 1, 1989·American Journal of Respiratory Cell and Molecular Biology·A D Stiles, B M Moats-Staats
Nov 1, 1988·The American Review of Respiratory Disease·P T Cagle, W M Thurlbeck
Jan 1, 1988·Experimental Lung Research·D E Rannels, S R Rannels
Mar 1, 1980·The American Review of Respiratory Disease·G SmithR Bone
Jan 1, 1995·American Journal of Respiratory Cell and Molecular Biology·B M Moats-StaatsA D Stiles
Apr 1, 1993·American Journal of Respiratory Cell and Molecular Biology·W A PriceA D Stiles
Jan 1, 1994·Annual Review of Physiology·P Minoo, R J King
May 1, 1997·American Journal of Respiratory Cell and Molecular Biology·K A Veness-MeehanA D Stiles
May 1, 1994·Molecular and Cellular Endocrinology·R ZarrilliA Riccio

❮ Previous
Next ❯

Citations

Feb 26, 2004·Paediatric Respiratory Reviews·Robert P Jankov, A Keith Tanswell
Apr 24, 2002·American Journal of Respiratory Cell and Molecular Biology·Yasushi SakamakiToshikazu Nakamura
Sep 10, 2005·American Journal of Respiratory Cell and Molecular Biology·Masahiro MaeRonald G Crystal
Dec 10, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Kristen ThaneAndrew M Hoffman
Aug 29, 2001·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·J C ValenciaV J Ferrans
Mar 5, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jun LiA Keith Tanswell
Oct 13, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·L J LandesbergR G Crystal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.