PMID: 15222271Jun 30, 2004Paper

Expression of the integrin alpha 6 beta 4 and effects of integrin alpha 6 beta 4 on adhesive and invasive behaviors of human laryngeal carcinoma cell lines

Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
Jiaqing ZhouXiaojie Jin

Abstract

To study the expression of integrin alpha 6 beta 4 in human laryngeal carcinoma cell lines Hep-2 and AMC-HN8. To explore the mechanism and the effects of integrin alpha 6 beta 4 in human laryngeal carcinoma cell lines. Flowcytometry was used to exame the surface expression of integrin alpha 6 beta 4 in human laryngeal carcinoma cell lines. Anti-alpha 6 and anti-beta 4 specific monoclonal antibody were used in adherence inhibition assay and in vitro invasion assay. Overexpression of integrin alpha 6 beta 4 were present in both Hep-2 and AMC-HN8 cell lines. Anti-alpha 6 and anti-beta 4 specific monoclonal antibody together blocked the alpha 6 beta 4 on the surface of the cells resulting in low adherence on the extracellular matrix and weak invasion through the extracellular matrix. Integrin alpha 6 beta 4 play a vitral role in the adhension and invasion of laryngeal carcinoma. Anti-alpha 6 and anti-beta 4 specific monoclonal antibody together can block the function of integrin alpha 6 beta 4. So treatment with anti-alpha 6 and anti-beta 4 specific monoclonal antibody may reduce the development of laryngeal carcinoma.

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