Expression of the integrin subunit alpha 9 in the murine embryo

Developmental Dynamics : an Official Publication of the American Association of Anatomists
A WangD Sheppard

Abstract

The alpha 9 integrin subunit is expressed in adult skeletal muscle, visceral smooth muscle, hepatocytes, squamous epithelium, and airway epithelium. The in vivo function of this protein is unknown. Thus far, only a single alpha 9-containing integrin has been identified (alpha 9 beta 1) and only a single ligand (tenascin) has been found for this integrin. In order to gain insight into the potential function of alpha 9 integrin(s), we examined the spatiotemporal distribution of the alpha 9 subunit and tenascin during murine embryogenesis. In all tissues where alpha 9 was expressed, its appearance was associated with other evidence of cell differentiation. In developing airway, visceral, and vascular smooth muscles, the onset of alpha 9 expression either coincided with or immediately followed the expression of alpha-SM actin. Expression of alpha 9 in epithelia was restricted to the choroid plexus and the basal cell layer of squamous epithelia where its appearance coincided with the development of stratification. alpha 9 immunostaining was first detected in developing skeletal musculature when skeletal myotubes formed. Tenascin expression was detected in many, but not all tissues found to express alpha 9. For example, the hair germ...Continue Reading

References

Apr 1, 1992·Muscle & Nerve·T Hurme, H Kalimo
Oct 1, 1992·Genes & Development·Y SagaS Aizawa
Mar 1, 1991·Experimental Lung Research·A A Ten Have-Opbroek
Dec 1, 1990·American Journal of Respiratory Cell and Molecular Biology·J J MitchellJ Woodcock-Mitchell
Nov 1, 1989·Scientific American·R Spector, C E Johanson
Jan 1, 1989·Annual Review of Cell Biology·H P Erickson, M A Bourdon
Jan 1, 1987·Differentiation; Research in Biological Diversity·O SkalliG Gabbiani
Feb 1, 1994·Developmental Dynamics : an Official Publication of the American Association of Anatomists·E D Kaplan, K A Holbrook
May 1, 1995·American Journal of Respiratory Cell and Molecular Biology·A WeinackerD Sheppard
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A L PrietoK L Crossin

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Citations

Oct 1, 2003·Experimental Cell Research·Monika TomczukJudith M White
Jun 2, 2012·The Journal of Biological Chemistry·Ryoko Sato-NishiuchiKiyotoshi Sekiguchi
Dec 3, 2004·Molecular Biology of the Cell·Peggy LafusteFrançois-Jérôme Authier
Jun 24, 2000·Molecular and Cellular Biology·X Z HuangD Sheppard
Apr 18, 2003·Cell Communication & Adhesion·John PetersMarianne Bronner-Fraser
Aug 1, 1996·Cell Adhesion and Communication·C A BuckH S Baldwin
Dec 24, 2005·Cell Communication & Adhesion·A K GeorgoliosK Charalabopoulos
Mar 2, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Ana Sofia CachaçoSólveig Thorsteinsdóttir
Mar 23, 2011·Developmental Biology·Sólveig ThorsteinsdóttirFernanda Bajanca
May 28, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Angelika C PaulMarilyn J Duxson
Feb 1, 1997·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M A Stepp, L Zhu
Jun 17, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L HäkkinenH Larjava
Mar 25, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M A Stepp
Jan 14, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Daisuke NanbaYohki Hieda
Oct 13, 2000·Breast Cancer : the Journal of the Japanese Breast Cancer Society·K ArihiroY Yokosaki
Dec 1, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Marianne DeriesSólveig Thorsteinsdóttir
Nov 8, 2017·Frontiers in Integrative Neuroscience·Jacqueline ReinhardAndreas Faissner
Feb 17, 2021·Cytokine & Growth Factor Reviews·Limor RubinPhilip Lazarovici
Sep 23, 2009·Developmental Biology·John T BenjaminLawrence S Prince

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