Expression of the JNK2-alpha1 gene in the developing chick brain

Biochemical and Biophysical Research Communications
T IshikawaT Nohnon

Abstract

We have isolated chicken JNK2-alpha1 encoding a c-Jun N-terminal kinase, and examined the expression during embryogenesis. The kinase domain sequence is well conserved between chicken and mammals, but carboxy-terminal sequence of JNK is divergent from subtype 1 and 2, possibly derived from alternative splicing. The JNK2-alpha1 gene is preferentially expressed in the neuroepithelium of developing brain at stages 16-26, and transcripts are not detectable in the other region including spinal cord. These results suggest that JNK2-alpha1 is involved in development of the central nervous system as a mediator of stress-activated protein kinase pathway conferring competence to the external stimuli such as growth factors.

Citations

Aug 7, 2007·Cytogenetic and Genome Research·S KatyalR Godbout
Apr 7, 2016·Scientific Reports·Ruiqin HanLinfang Wang
Jul 31, 2001·Developmental Biology·M GoswamiA K Sater

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