Expression of the Kv1.1 ion channel subunit in the auditory brainstem of the big brown bat, Eptesicus fuscus

The Journal of Comparative Neurology
Melissa H RosenbergerE Covey

Abstract

Voltage-gated potassium channels play an important role in shaping membrane properties that underlie neurons' discharge patterns and the ways in which they transform their input. In the auditory system, low threshold potassium currents such as those created by Kv1.1 subunits contribute to precise phaselocking and to transient onset responses that provide time markers for temporal features of sounds. The purpose of the present study was to compare information about the distribution of neurons expressing the KV 1.1 in the brainstem auditory nuclei with the distribution of neurons with known functional properties in the auditory system of the big brown bat, Eptesicus fuscus. We used immunocytochemistry and light microscopy to look at the distribution of Kv1.1 subunits in the brainstem auditory nuclei. There was prominent expression in cell types known to contain high levels of Kv1.1 in other species and known to respond to auditory signals with high temporal precision. These included octopus cells and spherical bushy cells of the cochlear nucleus and principal neurons of the medial nucleus of the trapezoid body. In addition, we found high levels of Kv1.1 in neurons of the columnar subdivision of the ventral nucleus of the lateral ...Continue Reading

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Citations

Jul 10, 2013·Journal of the Association for Research in Otolaryngology : JARO·Joshua X GittelmanChristine V Portfors
Feb 8, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Zoltán RusznákGéza Szucs
Jul 13, 2004·The European Journal of Neuroscience·Ursula KochBenedikt Grothe
Jan 21, 2015·Hearing Research·Anita KarczCornelia Kopp-Scheinpflug
Sep 22, 2007·Neuroscience Research·Hiroshi Kuba
Sep 23, 2016·Journal of Neurophysiology·Matthew J FischlConny Kopp-Scheinpflug
Apr 24, 2021·Journal of the Association for Research in Otolaryngology : JARO·Yaqing SuBertrand Delgutte

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