PMID: 7336172Oct 1, 1981Paper

Expression of the major histocompatibility complex antigens on different liver cellular components in rat and man

Scandinavian Journal of Immunology
I Lautenschlager, P Häyry

Abstract

We have analysed the distribution of the major histocompatibility complex (MHC) antigens on different liver cellular components in rat and man. Two types of antisera were used: monospecific rabbit antisera raised against isolated molecules of class I and class II and ordinary hyperimmune alloantisera directed to their allelic specificities. A modified Staphylococcus aureus rosette test, enabling morphological identification of the rosette-forming cell type, was used. In both species the passenger cells, especially the Kupffer cells reacted strongly with rabbit anti-class I and II. The passenger erythrocytes reacted with anti-class I in rat but not in man. Human liver vascular endothelial and bile duct cells displayed a distinct reaction with anti-class I and II, whereas the hepatocytes reacted only very weakly, if at all. In rat liver parenchymal component the expression of these antigens was different and weaker. Rat bile duct cells reacted with anti-class I and II in approximately 50% of the testings, whereas rat vascular endothelial cells and rat hepatocytes were essentially non-reactive. The alloantiserum reactivity (tested only in the rat) followed closely that of heterologous antisera, and the reactivity of anti-beta 2m t...Continue Reading

References

Oct 7, 1976·The New England Journal of Medicine·F H Bach, J J van Rood
Mar 1, 1978·Scandinavian Journal of Immunology·L KlareskogP A Peterson
Feb 1, 1978·Transplantation·P McMasterR Williams
Dec 14, 1978·Nature·K WimanP A Peterson
Jan 1, 1980·Scandinavian Journal of Immunology·P HäyryL C Andersson

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Citations

Nov 1, 1995·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·H ImamuraP M Huet
May 1, 1994·Transplant International : Official Journal of the European Society for Organ Transplantation·K YanoK Dohi
Apr 1, 1991·Transplant International : Official Journal of the European Society for Organ Transplantation·S KaruppanE Möller
Nov 21, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·M OertelK Kohlhaw
Dec 1, 1985·Journal of Clinical Pathology·S G HubscherP McMaster
Oct 1, 1988·Journal of Clinical Pathology·S G HubscherE Elias
Mar 1, 1990·Current Problems in Surgery·T E Starzl, A J Demetris
Jan 1, 1983·Scandinavian Journal of Immunology·I LautenschlagerP Häyry
Jan 1, 1984·Immunological Reviews·P HäyryR Renkonen
Oct 1, 1984·Scandinavian Journal of Immunology·I Lautenschlager
Jul 1, 1990·Journal of Hepatology·G Steinhoff
Nov 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H ShimizuR E Falk
Nov 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D H AdamsE Elias
Jun 1, 1995·Liver·M GuidoB Murer
Jul 1, 1991·Clinical and Experimental Immunology·R Sumimoto, T Shinomiya

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