Expression of the mammalian Na+-independent L system amino acid transporter in Xenopus laevis oocytes.

Archives of Biochemistry and Biophysics
S S TateS Udenfriend

Abstract

System L is primarily responsible for the Na+-independent transport of neutral amino acids, those with bulky chains such as leucine, isoleucine, phenylalanine, etc., into mammalian cells. mRNA from rat kidney and human lymphoid cells, when microinjected into Xenopus laevis oocytes, induced expression of this transport system. The expressed transport exhibits characteristics similar to those reported for the System L amino acid transporter from a variety of mammalian cells. Injection of size-fractionated mRNA indicates that the System L transporter in both the rat kidney and human lymphoid cells is encoded by mRNA of about 3 to 4 kb.

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Citations

Aug 1, 1994·Comparative Biochemistry and Physiology. Comparative Physiology·G Tunnicliff
Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S S TateS Udenfriend
Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J BertranH Murer
Sep 18, 1997·Kidney International·D G MatsellR W Chesney
Nov 15, 1990·Archives of Biochemistry and Biophysics·M J CoadyE M Wright
May 1, 1993·JPEN. Journal of Parenteral and Enteral Nutrition·K Gardiner, A Barbul
Aug 15, 1991·Archives of Biochemistry and Biophysics·T IshiiS Bannai
Jun 14, 1991·Biochemical and Biophysical Research Communications·S SeetharamB Seetharam

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