Expression of the mouse hepatitis virus receptor by central nervous system microglia

Journal of Virology
Chandran RamakrishnaStephen A Stohlman

Abstract

Detection of the mouse hepatitis virus receptor within the central nervous system (CNS) has been elusive. Receptor expression on microglia was reduced during acute infection and restored following immune-mediated virus control. Receptor down regulation was independent of neutrophils, NK cells, gamma interferon, or perforin. Infection of mice devoid of distinct inflammatory cells revealed CD4(+) T cells as the major cell type influencing receptor expression by microglia. In addition to demonstrating receptor expression on CNS resident cells, these data suggest that transient receptor down regulation on microglia aids in establishing persistence in the CNS by assisting virus infection of other glial cell types.

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Citations

Apr 7, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Susan J Bender, Susan R Weiss
Jan 18, 2006·Nature Reviews. Microbiology·Cornelia C BergmannStephen A Stohlman
Jan 7, 2010·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Hanae TakatsukiRihito Watanabe
Jul 1, 2006·Journal of Virology·Kathryn T IaconoSusan R Weiss
Dec 13, 2005·Microbiology and Molecular Biology Reviews : MMBR·Susan R Weiss, Sonia Navas-Martin
Nov 16, 2010·Journal of Neurovirology·Timothy J Cowley, Susan R Weiss
Jun 30, 2006·Mental Retardation and Developmental Disabilities Research Reviews·Li-Jin ChewMichael Bell
Jul 10, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joseph M AntonyChristopher Power
Nov 17, 2020·Frontiers in Veterinary Science·Peter J Dickinson

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