Expression of the multidrug-resistance-associated protein (MRP) gene in human colorectal, gastric and non-small-cell lung carcinomas

International Journal of Cancer. Journal International Du Cancer
Y ChumanT Aikou

Abstract

MRP has been identified as another multidrug-resistance (MDR) gene and may be involved in an alternative MDR mechanism in some solid tumors. We investigated the expression of MRP mRNA in multidrug-resistance KB sublines (KB-8-5, KB-C2, C-A40 and C-A120), human non-small-cell lung carcinomas (NSCLC), gastric and colorectal carcinomas, and compared it with that in drug-sensitive human KB cells. MRP gene expression was elevated in 8 of 9 (89%) squamous-cell carcinomas of the lung. Furthermore, MRP expression in 4 squamous-cell carcinomas (L13, 18, 19 and 20) was more than 3.6 times higher than in KB-3-1 cells, and the average MRP mRNA expression level of all squamous-cell carcinomas was significantly higher than that of adenocarcinoma of the lung and of colorectal and gastric carcinomas. These results suggested that the MRP is responsible, at least in part, for drug resistance in some squamous-cell carcinomas of the lung.

References

Nov 7, 1990·Journal of the National Cancer Institute·T MizoguchiS Akiyama
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A T FojoI Pastan
Jan 18, 1989·Journal of the National Cancer Institute·L J GoldsteinG M Brodeur
Aug 3, 1988·Biochimica Et Biophysica Acta·G BradleyV Ling
Mar 1, 1985·Somatic Cell and Molecular Genetics·S AkiyamaM M Gottesman
Dec 15, 1993·Journal of the National Cancer Institute·M F PouponT Le Chevalier
Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·G J ZamanH J Broxterman

❮ Previous
Next ❯

Citations

Aug 30, 2008·Human Pathology·Hajime KurodaShinji Itoyama
Oct 12, 2004·European Journal of Clinical Investigation·I AkanT Ozben
Sep 17, 2013·Journal of Cellular Biochemistry·Lin-Hai YanQiang Xiao
Dec 1, 1996·Japanese Journal of Cancer Research : Gann·M TomonagaS Kohno
Oct 23, 1997·International Journal of Cancer. Journal International Du Cancer·W BergerM Micksche
Nov 8, 2001·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Y SoiniV Kinnula

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.