Expression of the neural adhesion molecule L1 in the deafferented dentate gyrus

Neuroscience
M JuckerM Schachner

Abstract

Expression of the neural adhesion molecule L1 and its potential involvement in axonal sprouting were examined in the deafferented rat dentate gyrus. We focused on the dentate gyrus because of its well-defined cytoarchitecture and well-characterized neuronal degeneration and sprouting response following entorhinal cortex lesions. In the molecular layer of the dentate gyrus, a trilaminar staining pattern was observed, with the middle molecular layer exhibiting slightly denser immunolabeling compared to both inner and outer molecular layers. Two to 12 days after a unilateral entorhinal cortex lesion, a progressive loss of L1 immunolabeling was noted in the ipsilateral middle and outer molecular layers, followed by a substantial reappearance of immunostaining 65 days after lesion incidence. The width of the immunostained ipsilateral inner molecular layer revealed a progressive widening and by postlesion day 65 occupied about 50% of the total width of the molecular layer. Immunoelectron microscopy localized L1 to the surface of unmyelinated axons in both normal and deafferented dentate gyrus. In situ hybridization revealed L1 messenger RNA confined to neurons throughout the hippocampal formation, but did not indicate changes in L1 m...Continue Reading

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Citations

Mar 1, 2012·Cell and Tissue Research·Michael K E Schäfer, Michael Frotscher
Jan 1, 1995·Brain Research. Molecular Brain Research·M JuckerM Schachner
Jun 11, 2005·Molecular and Cellular Neurosciences·Michael SchäferThomas Brümmendorf
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