Expression of the neurokinin 1 receptor in the mouse retina

Neuroscience
E CatalaniG Casini

Abstract

Previous studies have revealed that the expression pattern of the neurokinin 1 receptor (the preferred receptor for substance P, SP) varies in different mammalian retinas. We investigated NK1 receptor expression in the mouse retina to provide background information for future studies in transgenic mice on SP functional roles in the retina. Mouse retinal sections were treated for single and double-label immunofluorescence. NK1 receptor immunoreactivity was in bipolar cells and in numerous amacrine cells. Double-label studies showed that NK1 receptor-expressing bipolar cells constituted a population of ON-type cone bipolar cells, since they were distinct from rod bipolar cells and contained glycine. They were nonrandomly distributed with highest density in central retina. These cells were similar and may correspond to the population of NK1 receptor-expressing bipolar cells of the rabbit retina. Different subsets of NK1 receptor-expressing amacrine cells were identified on the basis of the expression of selected neurotransmitter substances: i) about 23% of NK1 receptor-expressing amacrine cells also contained glycine; ii) the remaining 77% were likely to be GABAergic, although some inconsistency was observed in the GABA immunostai...Continue Reading

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Citations

May 22, 2010·Cornea·Hong-Yuan ZhuRoger W Beuerman
Jan 31, 2013·International Reviews of Immunology·Joan Stein-Streilein
Mar 1, 2006·The Journal of Comparative Neurology·Matthew J GastingerDavid W Marshak
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Sep 8, 2006·Peptides·Eduard SchmidJosef Troger
Nov 1, 2016·Genesis : the Journal of Genetics and Development·Huizhen HuangSarah E Ross
Jan 30, 2019·Critical Reviews in Clinical Laboratory Sciences·Julien FavresseFrançois Mullier
Jun 30, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kenyatta LucasJoan Stein-Streilein

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