Expression of the neuroprotective protein aryl hydrocarbon receptor nuclear translocator 2 correlates with neuronal stress and disability in models of multiple sclerosis

Journal of Neuroinflammation
Tissa RahimJacqueline Quandt

Abstract

Axonal degeneration and neuronal loss have been described as the major causes of irreversible clinical disability in multiple sclerosis (MS). The aryl-hydrocarbon receptor nuclear translocator 2 (ARNT2) protein has been associated with neuroprotection in models of ischemia and neuronal responses to stressors. To characterize its potential to influence inflammatory neurodegeneration, we examined ARNT2 expression in the experimental autoimmune encephalomyelitis (EAE) model of MS and characterized mediators that influence ARNT2 expression as well as plausible partners and targets. Arnt2 message and protein levels dropped significantly in EAE spinal cords as disease developed and were lowest at peak disability. ARNT2 expression is prominent in neuronal cell bodies within the gray matter with some staining in glial fibrillary acidic protein (GFAP)+ astrocytes in healthy animals. At peak disease, ARNT2 expression is reduced by 20-50% in gray matter neurons compared to healthy controls. ARNT2 intensity in neurons throughout the EAE spinal cord correlated inversely with the degree of immune cell infiltration (r = - 0.5085, p < 0.01) and axonal damage identified with SMI32 staining (r = - 0.376, p = 0.032). To understand the relationshi...Continue Reading

References

Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·L A Sternberger, N H Sternberger
Oct 1, 1995·Experimental Neurology·J Y KohD W Choi
Mar 1, 1997·Brain : a Journal of Neurology·B FergusonV H Perry
Jan 29, 1998·The New England Journal of Medicine·B D TrappL Bö
Apr 24, 1999·The European Journal of Neuroscience·G DrutelJ M Arrang
Apr 25, 2001·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·T HosoyaY Fujii-Kuriyama
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·B KeithM C Simon
Feb 15, 2002·Brain : a Journal of Neurology·D T ChardD H Miller
Sep 7, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Michael D LaiosaAllen E Silverstone
Sep 24, 2002·Brain : a Journal of Neurology·Tanja KuhlmannWolfgang Brück
Dec 28, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Marjo H Aitola, Markku T Pelto-Huikko
Jul 2, 2003·Neurotoxicity Research·Carl Bjartmar, Bruce D Trapp
Aug 7, 2003·Brain : a Journal of Neurology·G T IngleA J Thompson
Sep 18, 2004·Trends in Neurosciences·Mark P MattsonBronwen Martin
Nov 3, 2004·Growth Factors·Devin K Binder, Helen E Scharfman
Mar 18, 2005·Annual Review of Immunology·Mireia Sospedra, Roland Martin
Oct 19, 2005·Brain : a Journal of Neurology·Alexandra KutzelniggHans Lassmann
Dec 20, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·W RashidD H Miller
Mar 3, 2006·The New England Journal of Medicine·Elliot M FrohmanCedric S Raine
Apr 25, 2006·Multiple Sclerosis : Clinical and Laboratory Research·M H BarnettJ W Prineas
Aug 22, 2006·The Journal of Biological Chemistry·Xiaoping QiJohn Guy
Dec 13, 2006·The European Journal of Neuroscience·Mehrdad ShamlooKaroly Nikolich
Apr 5, 2007·Nature Protocols·Stefanie Kaech, Gary Banker
Jul 11, 2007·Journal of Neuropathology and Experimental Neurology·Riccardo Cassiani-IngoniMahendra S Rao
Sep 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·Seema Tiwari-WoodruffRhonda R Voskuhl
Sep 26, 2008·Nature·Yingxi LinMichael E Greenberg
Mar 19, 2009·Brain : a Journal of Neurology·Don J MahadDouglass M Turnbull
Aug 12, 2009·Current Neurology and Neuroscience Reports·Kimmy G SuMichael Forte
Jul 6, 2010·Biochimica Et Biophysica Acta·Jack van HorssenHelga E de Vries
Nov 9, 2010·The Journal of Biological Chemistry·Mytyl AigaShernaz X Bamji
Mar 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Priit PruunsildTõnis Timmusk
Oct 21, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gianluigi GuidottiMarco A Riva
Jul 19, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Zhaohui ZhangJinggui Song
Aug 3, 2013·Pharmacological Reviews·Francisco J Quintana, David H Sherr

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Citations

May 23, 2020·Neurology. Neuroimmunology and Neuroinflammation·Pierre BecquartJacqueline A Quandt
Dec 29, 2020·Brain Research Bulletin·Ankan SarkarPallab Bhattacharya

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Methods Mentioned

BETA
nuclear translocation
Fluorescence

Software Mentioned

Zeiss Zen
LightCycler® 480
GraphPad Prism

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