PMID: 9539366Apr 16, 1998Paper

Expression of the neutrophil chemoattractant interleukin-8 in the lesions of bovine pneumonic pasteurellosis

Veterinary Pathology
J L CaswellJohn R Gordon

Abstract

We investigated the expression of interleukin-8 (IL-8) in pneumonic pasteurellosis of cattle because neutrophils are important mediators of tissue injury in this disease and because IL-8 is a major neutrophil chemoattractant in other species. We also compared IL-8 expression in bacterial and viral pneumonia, since the latter lacks the severe neutrophil exudation typical of pneumonic pasteurellosis. IL-8 expression was assessed by northern analysis, in situ hybridization, enzyme-linked immunosorbent assay, and in vivo bioassay. IL-8 mRNA expression was elevated dramatically in lesions of pneumonic pasteurellosis compared to unaffected lung from the same calves. In situ hybridization revealed intense expression of IL-8 mRNA in alveolar macrophages and neutrophils and milder expression in bronchiolar and alveolar epithelium, interstitial cells, and pleural mesothelium. Bronchoalveolar lavage fluid from lesional lung contained 16.06+/-4.00 ng/ml IL-8, whereas those from nonlesional and normal lung contained 0.34+/-0.11 and 0.01+/-0.002 ng/ml, respectively. We detected IL-8 expression at only minimal levels in bovine respiratory syncytial viral pneumonia. Lung extracts from lesions of pneumonic pasteurellosis induced vigorous neutro...Continue Reading

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Citations

Mar 6, 2004·Microbial Pathogenesis·C MalazdrewichS K Maheswaran
Apr 13, 2000·Veterinary Immunology and Immunopathology·C L Galligan, B L Coomber
May 15, 2002·Veterinary Immunology and Immunopathology·Venu GangurSirinart Thanesvorakul
Jun 20, 2002·Veterinary Immunology and Immunopathology·Ernst C SoethoutVictor P M G Rutten
Jul 20, 2002·Veterinary Immunology and Immunopathology·L G PedersenB Aasted
Nov 3, 2005·American Journal of Veterinary Research·David J McClenahanCharles J Czuprynski
Aug 21, 2001·Biochemical and Biophysical Research Communications·F Li, J R Gordon
Sep 8, 2015·Veterinary Immunology and Immunopathology·L DoullG Entrican
Nov 15, 2006·Journal of Comparative Pathology·J C Hodgson
May 6, 2006·Comparative Immunology, Microbiology and Infectious Diseases·David McClenahanCharles Czuprynski
Oct 2, 2012·Microbial Pathogenesis·Katrina M HellenbrandNicole A Aulik
Jan 9, 2001·The Veterinary Journal·B L CoomberP A Gentry
Mar 8, 2016·Journal of Dairy Science·M AlbenzioA Sevi
Dec 5, 2014·PLoS Neglected Tropical Diseases·Ana Claudia Paiva Alegre-MallerMaria Cristina Roque-Barreira
Apr 9, 2017·Veterinary Research·Sean R WattegederaGary Entrican
Aug 6, 2010·Veterinary Pathology·K SinghA W Confer
Mar 23, 2000·Respirology : Official Journal of the Asian Pacific Society of Respirology·S Z Wang, K D Forsyth
Nov 13, 2001·American Journal of Veterinary Research·S D SwainM T Quinn
May 10, 2000·American Journal of Veterinary Research·D McClenahanD Weiss

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