PMID: 8951795Oct 1, 1996Paper

Expression of the Notch 3 intracellular domain in mouse central nervous system progenitor cells is lethal and leads to disturbed neural tube development

Mechanisms of Development
M LardelliU Lendahl

Abstract

Notch-like receptors are found in organisms ranging from nematodes to mammals. In Drosophila, Notch plays a key role in cell fate decisions in the early nervous system. In this report we analyse the effects of excess Notch 3 activity in central nervous system (CNS) progenitor cells. A mutated Notch gene encoding the intracellular domain of mouse Notch 3 transcribed from the nestin promoter was expressed in CNS progenitor cells in transgenic mice. This mutation resulted in a phenotypic series of neural tube defects in embryonic day 10.5-12.5 embryos and proved lethal to embryos beyond this age. In the milder phenotype the neural tube displayed a zig-zag morphology and the CNS was slightly enlarged. More severely affected embryos showed a lack of closure of the anterior neural pore, resulting in the externalization of neural tissue and the complete collapse of the third and fourth ventricles. The expanded ventricular zone of the neuroepithelium, a correspondingly enlarged area of nestin expression, and an increase in the number of proliferating cells in the neural tube suggested that these phenotypes resulted from an expanded CNS progenitor cell population. These data provide support in vivo for the notion that Notch activity pla...Continue Reading

References

May 1, 1977·Developmental Biology·M E Desmond, A G Jacobson
Mar 22, 1991·Cell·P Heitzler, P Simpson
Mar 1, 1981·Bioscience Reports·J N Wood, B H Anderton
Sep 28, 1995·Nature·S JarriaultA Israel
Jun 29, 1995·Nature·P Simpson
Jun 29, 1995·Nature·D HenriqueD Ish-Horowicz
Mar 1, 1995·Neuron·R I DorskyW A Harris
Mar 24, 1995·Cell·C E LindsellG Weinmaster
Apr 14, 1995·Science·S Artavanis-TsakonasM E Fortini
Mar 1, 1995·Trends in Genetics : TIG·A J Copp
Oct 21, 1994·Cell·M E Fortini, S Artavanis-Tsakonas
Feb 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·R KopanJ S Nye

❮ Previous
Next ❯

Citations

Jun 19, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·U Lendahl
Jan 26, 1999·Developmental Biology·P J Yaworsky, C Kappen
Mar 19, 2002·Progress in Neurobiology·Lukas Sommer, Mahendra Rao
Feb 28, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·N KishiK Matsuno
Apr 12, 2003·Seminars in Immunology·Kenji TanigakiTasuku Honjo
May 23, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·James Walsh, Peter W Andrews
Nov 19, 2008·Genes & Development·Xinwei CaoFred H Gage
Jan 1, 1997·Acta Anaesthesiologica Scandinavica. Supplementum·U Lendahl
Jan 7, 2005·Anatomical Science International·Makoto Ishibashi
Oct 18, 2013·Cellular and Molecular Neurobiology·Hana KotasováJiří Pacherník
Feb 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Michael T TetzlaffStephen J Elledge
Dec 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Helena KarlströmJohan Lundkvist
Apr 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Atsushi SuzukiHideki Taniguchi
Dec 6, 1997·Current Opinion in Genetics & Development·R Kageyama, S Nakanishi
Aug 1, 1997·Current Opinion in Genetics & Development·E Robey
Mar 20, 2015·Metabolites·Tania M Puvirajesinghe, Jean-Paul Borg
Jun 5, 2012·Experimental Cell Research·Yi-Ting LinJenn-Yah Yu
Nov 30, 2005·Journal of Anatomy·Andrew J Copp
Feb 28, 2004·Clinical Genetics·J A HarperC J Guidos
Sep 25, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Erica D WatsonJames C Cross
Nov 18, 2009·The Journal of Pathology·Andrew J Copp, Nicholas D E Greene
Aug 29, 2014·Journal of Cellular and Molecular Medicine·Gabriel Rusanescu, Jianren Mao
Aug 25, 2004·Current Biology : CB·Jörg Betschinger, Jürgen A Knoblich
Nov 30, 2011·Molecular and Cellular Neurosciences·Reiko WatanabeYehoash Raphael
Feb 9, 2002·Genesis : the Journal of Genetics and Development·Caiying GuoCorrinne G Lobe
Dec 22, 1999·Nature Neuroscience·L RedmondA Ghosh
Sep 7, 1999·Nature·A ApelqvistH Edlund
Sep 19, 2003·Nature Reviews. Genetics·Andrew J CoppJennifer N Murdoch
Dec 21, 2006·Birth Defects Research. Part A, Clinical and Molecular Teratology·Muriel J Harris, Diana M Juriloff
Jul 1, 2005·American Journal of Physiology. Cell Physiology·David MorrowPaul A Cahill

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.