Expression of the onconeural CV2/CRMP5 antigen in thymus and thymoma

Journal of Neuroimmunology
Jean-Philippe CamdessanchéJean-Christophe Antoine

Abstract

Anti-CV2 antibodies (AB) react with the developmentally regulated neural proteins CRMPs and particularly with CRMP5. They occur with small cell lung cancer (SCLC) and thymoma. SCLCs universally express CRMP5. We investigated the expression of CRMPs in thymoma and thymus. In thymoma, none of the CRMPs were detected by immunohistochemistry in tumorous epithelial cells with specific antibodies including CRMP5 but an antibody reacting with a peptide common to the CRMPs labeled a 66-kDa protein in Western blot of rat brain, thymus, and thymoma extracts. Thus, the normal CRMP5 is probably not expressed by tumorous epithelial cells. These results indicate that the mechanisms leading to CRMP5 autoimmunization are different in SCLC and thymoma.

References

Jun 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·J C AntoineD Michel
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·R B Darnell
Aug 1, 1997·Microscopy Research and Technique·S Kato
Jul 4, 1998·European Journal of Biochemistry·T BykA Sobel
Nov 17, 1998·Journal of Neuroimmunology·A R JurjusR J Walsh
Aug 12, 1999·Annals of Neurology·A SchultzA Marx
Sep 14, 1999·Pathology, Research and Practice·A Vincent, N Willcox
Oct 19, 1999·The Journal of Clinical Investigation·K G FloresL P Hale
Dec 14, 1999·The European Journal of Neuroscience·J HonnoratJ C Antoine
Oct 10, 2002·Applied Immunohistochemistry & Molecular Morphology : AIMM·Hiroko KuwabaraHiroshi Mori
Oct 17, 2003·The New England Journal of Medicine·Robert B Darnell, Jerome B Posner
Sep 3, 2004·Nature Reviews. Immunology·Bruno Kyewski, Jens Derbinski
Nov 25, 2004·Annals of Neurology·Philipp StröbelAlexander Marx

❮ Previous
Next ❯

Citations

Jul 28, 2007·Cancer Immunology, Immunotherapy : CII·Sissel E MonstadChristian A Vedeler
Apr 4, 2007·Clinical and Experimental Immunology·A KnudsenC A Vedeler
Jun 4, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Tamara Vyshkina, Bernadette Kalman
Mar 3, 2017·Neurology·Estefanía Torres-VegaLuis Bataller
Jul 7, 2017·Current Opinion in Neurology·Jean-Christophe Antoine, Jean-Philippe Camdessanché
Oct 3, 2013·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Peter W Kaplan, Raoul Sutter
Oct 8, 2020·Journal of Neural Transmission·Niels Hansen, Charles Timäus

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.