Expression of the Pax2 transcription factor is associated with vestibular phenotype in the avian inner ear.

Developmental Neurobiology
Mark E Warchol, Guy P Richardson

Abstract

The paired-domain transcription factor Pax2 is involved in many facets of inner ear development, but relatively little is known about the expression or function of Pax2 in the mature ear. In this study, we have used immunohistochemical methods to characterize the expression patterns of Pax2 in the sensory organs of inner ears from posthatch chicks. Immunoreactivity for Pax2 was observed in the nuclei of most hair cells and supporting cells in the vestibular organs. In contrast, Pax2 expression in the chick cochlea was limited to hair cells located in the very distal (low frequency) region. We then used organotypic cultures of the chick utricle to examine changes in Pax2 expression in response to ototoxic injury and during hair cell regeneration. Treatment with streptomycin resulted in the loss of most Pax2 immunoreactivity from the lumenal (hair cell) stratum of the utricle. During the early phases of regeneration, moderate Pax2 expression was maintained in the nuclei of proliferating supporting cells. Expression of Pax2 in the hair cell stratum recovered in parallel with hair cell regeneration. The results indicate that Pax2 continues to be expressed in the mature avian ear, and that its expression pattern is correlated with a...Continue Reading

References

Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·G R Dressler, E C Douglass
Nov 1, 1989·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·M E Warchol, P Dallos
Aug 15, 1985·The Journal of Comparative Neurology·M Lavigne-RebillardR Pujol
May 1, 1993·The Journal of Comparative Neurology·P Weisleder, E W Rubel
Dec 9, 1997·Neuron·J T Corwin, J C Oberholtzer
Dec 16, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·V KalatzisC Petit
Jul 19, 2000·Journal of Neurocytology·M R HutsonK F Barald
Sep 11, 2001·Journal of the Association for Research in Otolaryngology : JARO·J I MatsuiE W Rubel
Jan 17, 2002·The Journal of Comparative Neurology·Grace Lawoko-KeraliMatthew Holley
Jan 17, 2002·Journal of Neurobiology·Jonathan E GaleJeffrey T Corwin
Jul 23, 2003·Development·Weiming ZhengPin-Xian Xu
Feb 27, 2004·Evolution & Development·Elizabeth K O'Brien, Bernard M Degnan
Jun 10, 2004·Journal of Neurobiology·Huawei LiStefan Heller
Jul 10, 2004·Developmental Biology·Quianna BurtonDoris K Wu
Oct 7, 2004·Gene Expression Patterns : GEP·Hortensia Sánchez-CalderónMatías Hidalgo-Sánchez
Nov 24, 2004·The International Journal of Developmental Biology·Joram Piatigorsky, Zbynek Kozmik
Jun 28, 2005·Gene Expression Patterns : GEP·Hortensia Sánchez-CalderónMatías Hidalgo-Sánchez
Jul 11, 2006·Brain Research·Michio MurakoshiHiroshi Wada
Aug 15, 2006·Biochemical Pharmacology·Deborah LangBruce A Ruggeri
Oct 21, 2006·Nature Reviews. Neuroscience·Matthew W Kelley
Apr 20, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Victoria E AbrairaLisa V Goodrich
Jul 20, 2007·Development·Bonnie E JacquesMatthew W Kelley

❮ Previous
Next ❯

Citations

Feb 24, 2010·Journal of the Association for Research in Otolaryngology : JARO·Mark E Warchol, Mireille Montcouquiol
Mar 6, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eric L Slattery, Mark E Warchol
Sep 6, 2012·International Journal of Molecular Sciences·Tian-Biao ZhouYan-Jun Zhao
May 3, 2014·Nature Protocols·Karl R Koehler, Eri Hashino
Sep 14, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sabine FreterRaj K Ladher
Jan 11, 2012·Renal Failure·Tian-Biao ZhouWei-Fang Huang
Jan 19, 2021·ACS Biomaterials Science & Engineering·Sevda PouraghaeiAlireza Moshaverinia
Aug 24, 2010·BMC Developmental Biology·Maxime BouchardBernd Fritzsch

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.