PMID: 9188553Jul 1, 1997Paper

Expression of the poliovirus receptor in intestinal epithelial cells is not sufficient to permit poliovirus replication in the mouse gut

Journal of Virology
S Zhang, V R Racaniello

Abstract

Although the initial site of poliovirus replication in humans is the intestine, previously isolated transgenic mice which carry the human poliovirus receptor (PVR) gene (TgPVR mice), which develop poliomyelitis after intracerebral inoculation, are not susceptible to infection by the oral route. The low levels of PVR expressed in the TgPVR mouse intestine might explain the absence of poliovirus replication at that site. To ascertain whether PVR is the sole determinant of poliovirus susceptibility of the mouse intestine, we have generated transgenic mice by using the promoter for rat intestine fatty acid binding protein to direct PVR expression in mouse gut. Pvr was detected by immunohistochemistry in the enterocytes and M cells of transgenic mouse (TgFABP-PVR) small intestine. Upon oral inoculation with poliovirus, no increase in virus titer was detected in the feces of TgFABP-PVR mice, and no virus replication was observed in the small intestine, although poliovirus replicated in the brain after intracerebral inoculation. The failure of poliovirus to replicate in the TgFABP-PVR mouse small intestine was not due to lack of virus binding sites, because poliovirus could attach to fragments of small intestine from these mice. These...Continue Reading

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Citations

Jul 23, 2005·Journal of Neurovirology·Andreina BajAntonio Toniolo
Dec 31, 2016·Human Antibodies·Natan SteinOfer Mandelboim
Jun 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ralph S Baric, Amy C Sims
Dec 8, 2015·The Journal of Biological Chemistry·Taketoshi MizutaniCoh-Ichi Nihei
Dec 29, 2004·Autoimmunity·J Lindsay Whitton, Ralph Feuer
Sep 18, 2012·Critical Reviews in Microbiology·Derrick LouzRob C Hoeben
Sep 19, 2003·The Journal of General Virology·A M BuismanT G Kimman
Dec 10, 2020·International Journal of Molecular Sciences·Dörthe MasemannYvonne Boergeling
Aug 15, 1998·Microbial Pathogenesis·A M DeatlyV R Racaniello
Jul 1, 1998·Clinical and Diagnostic Virology·H J Eggers
Nov 8, 2002·Trends in Molecular Medicine·Marc Lecuit, Pascale Cossart
May 12, 2005·Virus Research·Steffen MuellerJeronimo Cello

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