Expression of the proliferating cell nuclear antigen (PCNA) in the rat thyroid gland after exposure to bromide

Acta histochemica
Jan VelickýIvan Raska

Abstract

Analysis of expression of the proliferating cell nuclear antigen (PCNA) was used to determine the presumed hyperplastic character of morphological changes in the rat thyroid evoked by bromide administration. Male rats fed by a standard diet with determined iodine and bromine content were given potassium bromide. Control animals received no bromide. Experimental animals were given 10, 50 or 100 mg Br- per 11 drinking water for 16 and 66 days, or 100, 200, 400 mg Br-/l drinking water for 133 days. The thyroids of treated animals showed activation of growth of the epithelial follicular component as well as diffuse and focal microfollicular rearrangement of the parenchyma with higher follicular cells accompanied by a decrease of the amount of colloid even at low bromine concentrations (10-100 mg Br-/l drinking water). Using the PCNA-LI index (PCNA-positive nuclei.100/total number of follicular cell nuclei in the section), immunohistochemical analysis of PCNA in the nuclei of the follicular cells was carried out in parrafin sections. The index was significantly higher in bromide exposed animals (P < 0.01) and correlated well with the histological changes, with bromide concentration and with a increased mitotic activity of the follic...Continue Reading

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Citations

Aug 19, 2009·Chinese Journal of Integrative Medicine·Yong HanJia-jun Zhao
May 23, 1998·Acta histochemica·J VelickýI Raska
Apr 28, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Terrilyn A Richardson, Curtis D Klaassen
Mar 3, 2012·Journal of the American Veterinary Medical Association·Hope E Baird-HeinzLaura L Hungerford

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