Expression of the promyelocytic leukemia zinc-finger in T-lymphoblastic lymphoma and leukemia has strong implications for their cellular origin and greater association with initial bone marrow involvement

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Yoon K JeonSeong H Park

Abstract

The promyelocytic leukemia zinc-finger (PLZF) is essential for the development of innate T cells (as represented by natural killer T cells) for acquisition of their unique innate immune properties. We evaluated the PLZF protein expression in a variety of immature and mature lymphoid malignancies. PLZF was preferentially expressed in T-lymphoblastic lymphoma/acute lymphoblastic leukemia (T-LBL/ALL) in 50% of the 54 cases. Among 51 cases of peripheral T-cell lymphoma not otherwise specified, only one (2%) expressed PLZF. One mycosis fungoides case expressed PLZF in lymph node involved by tumor. Otherwise, PLZF was not detected in any other type of lymphoma. In T-LBL/ALL, PLZF expression was more common in CD4/CD8 double-negative (67%) or CD8 single-positive subtypes (73%) than in CD4/CD8 double-positive (13%) and CD4 single-positive subtypes (0%) (P=0.001). Importantly, PLZF and CD1a expression were mutually exclusive in T-LBL/ALL (P=0.001). This was also the case for T-cell receptor βF1 expression (P=0.000). Most (96%) of the PLZF-positive T-LBL/ALL cases showed initial bone marrow involvement compared with 39% of PLZF-negative cases (P=0.000). Based on these findings, we suggest that T-LBL/ALLs that express PLZF arise from earl...Continue Reading

References

Jun 3, 2000·Nature Genetics·M BarnaP P Pandolfi
Apr 6, 2001·The American Journal of Pathology·Y K ShinS H Park
Feb 28, 2002·Annual Review of Immunology·Charles A Janeway, Ruslan Medzhitov
Mar 25, 2004·Nature Reviews. Immunology·Dale I GodfreyLuc Van Kaer
May 25, 2004·Nature Genetics·José A CostoyaPier Paolo Pandolfi
Sep 26, 2006·Trends in Cell Biology·Kevin F Kelly, Juliet M Daniel
Mar 21, 2007·American Journal of Clinical Pathology·Xin Han, Carlos E Bueso-Ramos
Nov 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Fabien GuidezDavid Grimwade
Nov 26, 2008·Immunology and Cell Biology·You Jeong LeeSeong Hoe Park
Jun 24, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elaine Coustan-SmithDario Campana
Sep 3, 2009·Genes & Development·Sergei DoulatovJohn E Dick
Oct 3, 2009·Annals of the New York Academy of Sciences·John E Dick, Sergei Doulatov
Jan 25, 2011·Current Opinion in Immunology·Eric S Alonzo, Derek B Sant'Angelo

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Citations

Dec 19, 2015·European Journal of Haematology·Renato BassanSergio Cortelazzo
Mar 2, 2018·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Alexey P OrlovDmitry A Kuznetsov
Nov 6, 2018·Blood·Rémy RobinotLaurent Genestier
Jun 18, 2019·Hypertension·Guido GrassiGiuseppe Mancia
Jun 7, 2015·Human Nature : an Interdisciplinary Biosocial Perspective·Jacob M VigilJane Ellen Smith

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