PMID: 11906548Mar 22, 2002Paper

Expression of the protease inhibitor antileukoprotease and the serine protease stratum corneum chymotryptic enzyme (SCCE) is coordinated in ovarian tumors

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
K ShigemasaT J O'Brien

Abstract

We have previously reported that the stratum corneum chymotryptic enzyme (SCCE) is overexpressed in ovarian cancers and that SCCE has potential as a useful marker and/or a therapeutic target for ovarian carcinoma. Antileukoprotease (ALP) has been shown to be a specific inhibitor of SCCE. The objective of this study was to investigate the potential cotranscription and overexpression of ALP in carcinoma of the ovary. The expression of ALP transcript was evaluated by Northern blot hybridization and by semiquantitative polymerase chain reaction (PCR) technique. The presence of the ALP protein in ovarian tumor cells was evaluated by immunohistochemistry. Northern blot hybridization showed that the ALP transcript was abundant in ovarian carcinomas but was not detected in the normal ovary. Semi-quantitative PCR examination revealed that the mRNA level of ALP was significantly elevated in low-malignant-potential tumors and in ovarian carcinomas compared with that in normal ovaries (P < 0.01). There was significant positive correlation between SCCE and ALP mRNA overexpression status in ovarian tumor cases (P < 0.01). Immunohistochemical expression of ALP protein was observed in ovarian tumor cells, whereas little or no staining was obse...Continue Reading

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Citations

Dec 23, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Carl KapadiaEleftherios P Diamandis
Dec 19, 2008·BMC Cancer·Vishnu C RamaniRandy S Haun
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Aug 3, 2005·Cancer Research·Kenneth MacleodSimon P Langdon
Feb 20, 2021·Cytokine & Growth Factor Reviews·Sandrine Nugteren, Janneke N Samsom
Nov 4, 2008·Archives of Pathology & Laboratory Medicine·Qiang XuanZeng-Nan Mo

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