Expression of the Receptor for Advanced Glycation End Products in Epicardial Fat: Link with Tissue Thickness and Local Insulin Resistance in Coronary Artery Disease

Journal of Diabetes Research
Elena DozioM M Corsi Romanelli

Abstract

Increased expression of receptor for advanced glycation end products (RAGE) in adipose tissue has been associated with inflammation, adipocyte hypertrophy, and impaired insulin signal. Epicardial adipose tissue (EAT), a visceral fat surrounding the myocardium, is potentially involved in the onset/progression of coronary artery disease (CAD). To date, the role of RAGE in EAT has not been explored much. We examined whether the RAGE expression in EAT was associated with EAT adiposity and metabolic dysfunctions normally found in CAD patients. EAT samples were obtained from 33 patients undergoing open-heart surgery. EAT expression of RAGE, GLUT4, adiponenctin, GLO1, HMGB1, TLR-4, and MyD88 was analyzed by microarray. EAT thickness was quantified by echocardiography. Anthropometric measures and clinical parameters were taken. BMI, HOMA-IR, and LAP indices were calculated. With increasing RAGE expression in EAT we observed increases in EAT thickness, reduced expression of GLUT4, adiponectin, and GLO1, and elevations of HMGB1, TLR-4, and MyD88. There were significant correlations between RAGE and EAT thickness and between RAGE and the genes. LAP was higher in patients with increased RAGE expression. Our data suggest that in CAD patient...Continue Reading

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Citations

Oct 26, 2016·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·S MarianiL Gnessi
Dec 28, 2018·Circulation·Marisol Ruiz-MeanaDavid Garcia-Dorado
Dec 15, 2019·International Journal of Molecular Sciences·Federico BiscettiAndrea Flex
Feb 12, 2020·Journal of Clinical Medicine·Elena DozioMassimiliano Marco Corsi Romanelli
Dec 26, 2019·Scientific Reports·Clarissa Strieder-BarbozaRobert W O'Rourke
Sep 18, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Tiago RodriguesPaulo Matafome

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Methods Mentioned

BETA
coronary artery bypass
biopsy
Feature Extraction

Software Mentioned

ChipInspector
GraphPad
GraphPad Prism
Agilent Feature Extraction
SAM

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