PMID: 11331667May 2, 2001Paper

Expression of the second isoform of gonadotrophin-releasing hormone (GnRH-II) in human endometrium throughout the menstrual cycle

Molecular Human Reproduction
K W CheonI S Kang

Abstract

We examined the expression of the protein and mRNA of the newly cloned isoform of human gonadotrophin-releasing hormone (GnRH-II) in the normal human endometrium during the menstrual cycle. Nested RT-PCR and sequence analysis revealed that two spliced variants of GnRH-II mRNA were expressed during the entire menstrual cycle, with the shorter transcript having a 21 nucleotide deletion in the region coding for GnRH-associated peptide. Using immunohistochemistry, we identified immunoreactive GnRH-II in both stromal and glandular epithelial cells during the entire menstrual phase. The immunostaining intensity was stronger during the early and mid-secretory phase compared with the proliferative and late-secretory phase. A large amount of immunoreactive GnRH-II was localized in the apical pole of the glandular lumen. Our results show that the second isoform of GnRH (GnRH-II) is expressed in the human endometrium during the entire menstrual phase. We also suggest that an increased expression of endometrial GnRH-II peptide, noted during the early and mid-secretory phase, may play an important role in human embryo implantation.

References

Jan 11, 1975·American Journal of Obstetrics and Gynecology·J M GibbonsV Chieffo
Sep 13, 1991·European Journal of Obstetrics, Gynecology, and Reproductive Biology·G S PahwaG Emons
Jan 20, 1991·The New England Journal of Medicine·P M Conn, W F Crowley
Mar 1, 1983·Endocrinology·S BhasinR Swerdloff
Jan 18, 1980·Science·G S Khodr, T M Siler-Khodr
Apr 1, 1993·Endocrine Reviews·N M SherwoodI R Coe
Sep 5, 1996·Brain Research. Molecular Brain Research·I S ParharM Schwanzel-Fukuda
Aug 1, 1996·Seminars in Reproductive Endocrinology·S I Tazuke, L C Giudice
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·R B WhiteR D Fernald
Jun 24, 1998·Biochemical and Biophysical Research Communications·J T MooreT M Willson
May 20, 1999·Molecular Human Reproduction·E M CasañM L Polan

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Citations

Aug 9, 2011·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Min XiongGuijin Zhu
Dec 12, 2002·Trends in Endocrinology and Metabolism : TEM·Robert P Millar
Mar 6, 2010·Molecular Human Reproduction·Xiaomei ZhangSergio Oehninger
Jun 15, 2011·Current Opinion in Obstetrics & Gynecology·Orkun Tan, Orhan Bukulmez
Feb 12, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Hsien-Ming WuPeter C K Leung
Aug 22, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·G B GodboleC P Puri
Aug 27, 2014·Human Reproduction Update·Daniela GallianoAntonio Pellicer
Dec 31, 2015·Human Reproduction Update·Roberto MaggiPatrizia Limonta
Jul 25, 2006·Contraception·Theresa M Siler-KhodrYi-Xun Lui
May 3, 2006·Theriogenology·Falk SchneiderCarsten Gründker
Jan 15, 2014·Scientific Reports·Wei XiaYonathan Zohar
Jan 10, 2018·Frontiers in Endocrinology·Amy T DesaulniersBrett R White
Jul 23, 2005·Human Reproduction·Chieko MorimotoYuji Taketani
May 15, 2008·The Journal of Clinical Endocrinology and Metabolism·In-Sun HongPeter C K Leung
May 5, 2005·The Journal of Clinical Endocrinology and Metabolism·Kaushik MaitiJae Young Seong
Jul 11, 2012·Endocrine Reviews·Patrizia LimontaRoberta M Moretti
Oct 19, 2017·Journal of Periodontal Research·H Balci YuceH Toker
Jan 1, 2006·Expert Review of Endocrinology & Metabolism·Alexander S Kauffman, Emilie F Rissman
Oct 13, 2020·Frontiers in Neuroendocrinology·Hsien-Ming WuPeter C K Leung
Dec 18, 2020·International Journal of Molecular Sciences·Fabrizio FontanaPatrizia Limonta

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