Expression of the serine/threonine kinase hSGK1 in chronic viral hepatitis

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Sophie FillonFlorian Lang

Abstract

The human serine/threonine kinase hSGK1 is expressed ubiquitously with highest transcript levels in pancreas and liver. This study has been performed to determine the hSGK1 distribution in normal liver and its putative role in fibrosing liver disease. HSGK1-localization was determined by in situ hybridization, regulation of hSGK1-transcription by Northern blotting, fibronectin synthesis and hSGK1 phosphorylation by Western blotting. In normal liver hSGK1 was mainly transcribed by Kupffer cells. In liver tissue from patients with chronic viral hepatitis, hSGK1 transcript levels were excessively high in numerous activated Kupffer cells and inflammatory cells localized within fibrous septum formations. HSGK1 transcripts were also detected in activated hepatic stellate cells. Accordingly, Western blotting revealed that tissue from fibrotic liver expresses excessive hSGK1 protein as compared to normal liver. TGF-beta1 (2 ng/ml) increases hSGK1 transcription in both human U937 macro-phages and HepG2 hepatoma cells. H(2)O(2) (0.3 mM) activated hSGK1 and increased fibronectin formation in HepG2 cells overexpressing hSGK1 but not in HepG2 cells expressing the inactive mutant hSGK1(K127R). In conclusion hSGK1 is upregulated by TGF-beta1 ...Continue Reading

Citations

Jan 11, 2008·Journal of the American Society of Nephrology : JASN·Yoshio TeradaSei Sasaki
Oct 10, 2008·Journal of Virology·Mathis Heydtmann
Dec 20, 2005·The Journal of Membrane Biology·F LangS M Huber
Feb 8, 2006·Annual Review of Physiology·Johannes LoffingOlivier Staub
May 20, 2006·Kidney & Blood Pressure Research·Yuxi FengFlorian Lang
Mar 6, 2008·Kidney & Blood Pressure Research·Azeemudeen HussainFlorian Lang
Mar 18, 2006·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Amanda W WyattFlorian Lang
Dec 15, 2006·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Gottlieb MaierFlorian Lang
Apr 11, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Volker VallonFlorian Lang
Aug 23, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ferruh ArtuncFlorian Lang
Oct 11, 2008·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Quansheng WangZhonghua Zhu
Dec 22, 2009·Expert Opinion on Therapeutic Patents·Florian Lang, Agnes Görlach
Jul 16, 2003·American Journal of Obstetrics and Gynecology·Bertha ChenMary Lake Polan
Dec 3, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Maria W SmithMichael G Katze
Nov 23, 2005·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yuxi FengFlorian Lang
Mar 14, 2003·Pflügers Archiv : European journal of physiology·Hamdy M EmbarkFlorian Lang
Oct 6, 2010·Growth Factors·Maressa A BruhnKaren E Sheppard
Jan 26, 2005·Biochemical Society Transactions·F LangC Böhmer
Mar 27, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·M PalmadaF Lang
Sep 5, 2008·American Journal of Physiology. Renal Physiology·Ferruh ArtuncFlorian Lang
Dec 4, 2020·Pharmaceuticals·Ilaria GuerrieroArturo Orlacchio
Apr 6, 2019·Current Medicinal Chemistry·Shahram GolbabapourBita Geramizadeh
Dec 18, 2004·Journal of Cellular Physiology·Ekaterina ShumilinaFlorian Lang
Feb 18, 2006·Biochemical Pharmacology·Sabine C WolfBernhard R Brehm
Feb 24, 2007·Archives of Biochemistry and Biophysics·Florian LangErich Gulbins

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.

Related Papers

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Craig D AlbrightSteven H Zeisel
Biochemical Pharmacology
Carl D Bortner, John A Cidlowski
Proceedings of the National Academy of Sciences of the United States of America
Emi MaenoYasunobu Okada
Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Rosa TeijeiroVictor M Arce
© 2022 Meta ULC. All rights reserved