PMID: 8590455Apr 1, 1995Paper

Expression of the small heat shock protein (hsp) 27 in human astrocytomas correlates with histologic grades and tumor growth fractions

Cellular and Molecular Neurobiology
H KhalidS Shibata

Abstract

1. Cellular expression and distribution of the stress response small heat shock protein 27 (hsp27) in 39 high-grade astrocytomas (27 glioblastoma multiformes, 12 anaplastic astrocytomas) and in 27 low-grade astrocytomas (grade I-II) were analyzed immunohistochemically. 2. The correlation between hsp27 expression and tumor growth fractions of the astrocytomas was examined following Ki-67 immunostaining. 3. The hsp27 staining was cell cytoplasmic. The hsp27 immunopositive rate was significantly higher in high-grade astrocytomas; the rates was 74% for glioblastomas, 58% for anaplastic astrocytomas, and 37% for low-grade astrocytomas. The small and large tumor cells, especially in glioblastomas, multinucleated tumor giant cells, tumor cells in the pseudopalisading and necrotic areas, cells of the microvascular endothelial proliferations, and tumor vascular smooth muscles were usually hsp27 positive. The mean percentage of hsp27-positive cells was significantly higher in the glioblastomas alone and in the combined high-grade astrocytomas, compared to the low-grade, and in recurrent rather than in primary high-grade astrocytomas. 4. The high-grade astrocytomas had a highly statistical significant Ki-67 labeling index. The Ki-67 label...Continue Reading

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Citations

Jul 11, 2006·Journal of Pediatric Hematology/oncology·Péter HauserMiklós Garami
Jul 26, 2005·Cell Stress & Chaperones·Daniel R Ciocca, Stuart K Calderwood
Jun 10, 2014·Pharmacological Reports : PR·Dorota BądziulAntoni Gawron
Dec 1, 2009·Neurosurgery Clinics of North America·Isaac YangAndrew T Parsa
Mar 21, 2006·The International Journal of Biochemistry & Cell Biology·Huaiyong ChenXun Shen
Mar 30, 1999·Experimental Cell Research·M Jäättelä
Mar 13, 2016·Journal of Cellular Biochemistry·Shanshan WangGeorge G Chen
Dec 2, 2000·Cell Proliferation·K HelmbrechtL Rensing
May 24, 2001·The Journal of Urology·B KhoubehiC W Ogden
Nov 28, 2002·Blood·Nancy D BorsonPeter J Wettstein
Jan 12, 2017·Oncotarget·Sami BenzinaGilles A Robichaud
Aug 22, 2000·Journal of Neuropathology and Experimental Neurology·S ErdamarR G Grossman

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