Expression of the transcription factor, TFII-I, during post-implantation mouse embryonic development.

BMC Research Notes
Iwona FijalkowskaSonye K Danoff

Abstract

General transcription factor (TFII-I) is a multi-functional transcription factor encoded by the Gtf2i gene, that has been demonstrated to regulate transcription of genes critical for development. Because of the broad range of genes regulated by TFII-I as well as its potential role in a significant neuro-developmental disorder, developing a comprehensive expression profile is critical to the study of this transcription factor. We sought to define the timing and pattern of expression of TFII-I in post-implantation embryos at a time during which many putative TFII-I target genes are expressed. Antibodies to the N-terminus of TFII-I were used to probe embryonic mouse sections. TFII-I protein is widely expressed in the developing embryo. TFII-I is expressed throughout the period from E8-E16. However, within this period there are striking shifts in localization from cytoplasmic predominant to nuclear. TFII-I expression varies in both a spatial and temporal fashion. There is extensive expression in neural precursors at E8. This expression persists at later stages. TFII-I is expressed in developing lung, heart and gut structures. There is no evidence of isoform specific expression. Available data regarding expression patterns at both a...Continue Reading

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Citations

May 20, 2016·Genesis : the Journal of Genetics and Development·Badam EnkhmandakhDashzeveg Bayarsaihan
Aug 19, 2018·Molecular Neurobiology·Marielle H S DeurlooZhong-Ping Feng
May 15, 2012·American Journal of Human Genetics·Carolyn B MervisLucy R Osborne

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