PMID: 9541211Apr 16, 1998Paper

Expression of the transcription factors Otlx2, Barx1 and Sox9 during mouse odontogenesis

European Journal of Oral Sciences
Thimios A MitsiadisC Goridis

Abstract

The molecular mechanisms governing the decision between molariform and incisiform patterns of rodent dentition are not yet known. Transcription factors are regulators of regionally specific morphogenesis and key co-ordinators of gene activity during developmental processes. Here, we analysed the expression of several transcription factors during mouse tooth development. Otlx2/Rieg is a homeobox gene involved in Rieger syndrome, a human disorder characterized by dental hypoplasia. Otlx2/Rieg expression distinguishes stomatodeal epithelium well before tooth initiation, and thereafter its expression becomes restricted to the epithelia of both molar and incisor primordia. The recently identified homeodomain transcription factor Barx1 is first expressed in mesenchyme of the first branchial arch, but during advanced developmental stages the gene is exclusively expressed in the mesenchyme of molar primordia. Finally, the Sry-related transcription factor Sox9 is expressed in epithelial components and to a lesser degree in condensed mesenchyme of the developing teeth. These results suggest that Otlx2/Rieg, Barx1, and Sox9 participate in the hierarchical cascade of factors involved in the regulation of tooth morphogenesis.

Citations

Jul 22, 2008·Development Genes and Evolution·Ann HuysseunePaul Eckhard Witten
Jan 18, 2011·Trends in Molecular Medicine·James PritchettKaren Piper Hanley
May 24, 2008·European Journal of Medical Genetics·Isabelle Bailleul-ForestierAriane Berdal
Feb 24, 2007·Seminars in Cell & Developmental Biology·Marja L Mikkola
Jan 14, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kevin TompkinsArthur Veis
Sep 15, 2009·Birth Defects Research. Part C, Embryo Today : Reviews·Thimios A Mitsiadis, Daniel Graf
Jan 22, 2009·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Moya M SmithThimios A Mitsiadis
May 7, 2008·Journal of Cellular Physiology·Olivier Duverger, Maria I Morasso
Aug 9, 2011·Clinical Genetics·T A Mitsiadis, H U Luder
May 29, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Kenta UchibeHiroshi Asahara
Sep 7, 2013·Wiley Interdisciplinary Reviews. Developmental Biology·Andrew H JheonOphir D Klein
Jan 11, 2002·Developmental Biology·M Mandler, A Neubüser
Feb 14, 2009·PLoS Biology·Gareth J FraserJ Todd Streelman
Oct 18, 2001·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·M Mina
Dec 18, 2016·Journal of Endodontics·Manuel Marí-BeffaAránzazu Díaz-Cuenca
Dec 7, 2017·Frontiers in Physiology·Thimios A MitsiadisClaudio Cantù
Nov 7, 2020·Biochemical Society Transactions·Pierfrancesco PagellaThimios A Mitsiadis
Nov 6, 2015·Biology Open·Marcia GaeteAbigail S Tucker
Nov 17, 2006·Development·Feiyan DongJames F Martin

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