Expression of the trefoil peptides pS2 and human spasmolytic polypeptide (hSP) in Barrett's metaplasia and the native oesophageal epithelium: delineation of epithelial phenotype

The Journal of Pathology
A M HanbyN A Wright

Abstract

The distribution of the two trefoil peptides pS2 and human spasmolytic polypeptide (hSP) and their mRNAs was investigated in 90 selected oesophageal biopsies, 23 of which contained epithelium with wholly gastric cardiac-type morphology, 52 specialized (intestinal)-type metaplasia, and 15 non-metaplastic oesophageal epithelium. No fundic-type epithelium was represented. The cardiac-type epithelium resembled true gastric antral epithelium, with hSP and pS2 mRNA localization to the superficial/foveolar compartment and hSP mRNA alone in deeper glands. The pattern of peptide distribution was broadly in line with the mRNA, but hSP peptide was generally not demonstrable in the surface epithelium. pS2 immunostaining was diffusely cytoplasmic, whereas in specialized-type mucosa it was aggregated and cytoplasmic. hSP mRNA was demonstrable in surface epithelium of incomplete- but not complete-type intestinal (specialized) metaplasia. Deep glands with morphological features of pyloric glands/ulcer-associated cell lineage (UACL) typically contained only hSP peptide and its mRNA. In three biopsies containing specialized epithelium, small foci morphologically identical to true small intestinal surface epithelium were seen in which only pS2 mR...Continue Reading

References

Mar 1, 1985·Biochimica Et Biophysica Acta·L ThimK H Jørgensen
Mar 26, 1984·Nucleic Acids Research·S B JakowlewP Chambon
Apr 1, 1993·The Veterinary Clinics of North America. Equine Practice·S R Hance, A L Bertone

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Citations

May 11, 1999·The American Journal of Pathology·J A JankowskiL S Young
Jul 31, 1998·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·N A Wright
Jun 18, 2002·Journal of Cellular and Molecular Medicine·J R Jass, M D Walsh
May 14, 1999·Gut·W M WongN A Wright
Mar 1, 1996·Baillière's Clinical Gastroenterology·R Poulsom
Nov 27, 2014·Digestive Diseases and Sciences·Lorna J DunnS Michael Griffin
Nov 5, 2014·Nature Reviews. Gastroenterology & Hepatology·Stuart A C McDonaldMarnix Jansen
Jul 29, 2016·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·Anna K Brandtner, Michael Quante
Jun 13, 2002·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·J KleeffM W Büchler
Jun 28, 2018·Digestive Diseases and Sciences·Ramon U Jin, Jason C Mills
Jun 12, 2003·World Journal of Gastroenterology : WJG·Harry Hua-Xinag XiaBenjamin Chun-Yu Wong
Oct 22, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Concepcion Fernandez-EstivarizThomas R Ziegler
May 13, 2021·Best Practice & Research. Clinical Gastroenterology·Jan BornscheinMarnix Jansen

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