Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development

PMID: 2379826May 1, 1990

Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development

Genes & Development

D Martin-ZancaL F Parada

Abstract

We have cloned and characterized the mouse homolog of the human trk proto-oncogene, a member of the protein tyrosine kinase (TK) receptor gene family. Here, we present the first report of a trk-encoded mRNA species in vivo. In situ hybridization analysis in the mouse embryo reveals a striking temporal and spatial regulation of trk transcription, with expression confined to the sensory cranial (trigeminal, superior, jugular) and dorsal root ganglia (DRG) of neural crest origin. Recent reports have shown that TK receptors can play regulatory roles in embryonic development. Thus, the developmental mutations W in mouse and torso and sevenless in Drosophila represent genes that code for defective TK receptors. Our data show that trk, a gene associated with malignancy in humans, is a specific marker for a set of neural crest-derived sensory neurons, and are consistent with the hypothesis that this proto-oncogene may have an important role in the development or phenotype of the neurons where it is expressed.

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Longitudinal determination of skin collagen glycation and glycoxidation rates predicts early death in C57BL/6NNIA mice

Jan 8, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D R SellV M Monnier

Exome sequencing identifies novel NTRK1 mutations in patients with HSAN-IV phenotype

Mar 23, 2017·American Journal of Medical Genetics. Part a·Ruqaiah AltassanSalma M Wakil

Rearrangements of TRK proto-oncogene in papillary thyroid carcinomas

Feb 1, 1995·Journal of Endocrinological Investigation·M A PierottiA Greco

Altered immediate early gene expression in injured diabetic nerve: implications in regeneration

Oct 9, 2001·Journal of Neuropathology and Experimental Neurology·G Xu, Anders A F Sima

Opposite regulation of calbindin and calretinin expression by brain-derived neurotrophic factor in cortical neurons

May 9, 2000·Journal of Neurochemistry·H FiumelliJ L Martin

Expression of nerve growth factor, p75, and trk in the somatosensory and motor cortices of mature rats: evidence for local trophic support circuits

Jan 1, 1995·Somatosensory & Motor Research·A F Pitts, M W Miller

Neuronal differentiation in human neuroblastoma cells by nerve growth factor following TrkA up-regulation by interferon-gamma

Jun 8, 2000·Medical and Pediatric Oncology·A ShikataT Sawada

Zhangfei induces the expression of the nerve growth factor receptor, trkA, in medulloblastoma cells and causes their differentiation or apoptosis

Aug 23, 2008·Journal of Neuro-oncology·Ximena ValderramaVikram Misra

Oncogenes and anti-oncogenes in human epithelial thyroid tumors

May 1, 1994·Journal of Endocrinological Investigation·S SaidH G Suarez

Insulin deficiency rather than hyperglycemia accounts for impaired neurotrophic responses and nerve fiber regeneration in type 1 diabetic neuropathy

Mar 18, 2003·Journal of Neuropathology and Experimental Neurology·Christopher R PiersonAnders A F Sima

Related Concepts

Ganglia

Ganglia, Spinal

Genes, Reiterated

Neural Groove

Protein Tyrosine Kinase

Proto-Oncogenes

Poly(A) Tail

Structure of Trigeminal Ganglion

Homologous Sequences, Nucleic Acid

Transcription, Genetic

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