Expression of three zebrafish orthologs of human FMR1-related genes and their phylogenetic relationships

Development Genes and Evolution
Ben TuckerMichael Lardelli

Abstract

The human fragile X mental retardation syndrome is caused by expansions of a CGG repeat in the FMR1 gene. FXR1 and FXR2 are autosomal paralogs of FMR1. The products of the three genes, FMRP, FXR1P, and FXR2P, respectively, belong to a family of RNA-binding proteins. While the FMR1-related gene family is well described in human, mouse and Drosophila, little is known about zebrafish (Danio rerio) orthologs of these genes. Here we collate the known FMR1-related gene sequences from zebrafish, examine their regions of structural conservation, and define their orthologies with the human genes. We demonstrate that zebrafish possess only three FMR1-related genes, fmr1, fxr1 and fxr2, and these are orthologous to the human FMR1, FXR1 and FXR2 genes respectively. We examine the spatiotemporal pattern of transcription of the zebrafish genes from 0 hours post fertilisation (hpf) until 24 hpf. Expression of fmr1, fxr1 and fxr2 is widespread throughout this time. However, relative to surrounding tissues, expression of fxr2 is raised in adaxial and somitic cells by 12 hpf while fxr1 expression is high in the anterior of the embryo, and is raised in adaxial cells by 12 hpf. Distinct patterns (and levels) of expression are seen for the differen...Continue Reading

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Citations

Jul 8, 2005·Molecular Biology of the Cell·Marc-Etienne HuotEdouard W Khandjian
Jun 6, 2012·Comparative and Functional Genomics·Paula Vazquez-Pianzola, Beat Suter
Jul 11, 2012·Neural Plasticity·Karen KelleyShi-Lung Lin
Apr 9, 2005·Development Genes and Evolution·Sandra van 't PadjeRob Willemsen
Mar 10, 2016·Neuroscience and Biobehavioral Reviews·Emilia RomanoBianca De Filippis
Jan 22, 2015·Intractable & Rare Diseases Research·Tatiana M KazdobaJacqueline N Crawley
Oct 12, 2013·American Journal of Medical Genetics. Part a·Claudia Bagni, Ben A Oostra
Jun 1, 2013·Developmental Neurobiology·Denise CookKeith K Murai
Nov 5, 2013·Neuroscience and Biobehavioral Reviews·Celine E F de EschRob Willemsen
Oct 1, 2011·Biomolecular Concepts·Claudia Winograd, Stephanie Ceman

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