Expression of thrombospondin-1 gene mRNA and protein in the placenta in gestosis

Bulletin of Experimental Biology and Medicine
Yu V OstankovaD I Sokolov

Abstract

The expression of TSP-1 gene mRNA and TSP-1 protein in the placental tissue was studied during normal pregnancy and in gestosis. The formation of placental tissue in normal gestation was associated with expression of TSP-1 gene mRNA and of TSP-1 protein. Gestosis was associated with inflammatory reaction in the placenta characterized by increased counts of lymphocytes and macrophages in the villous stroma and involution degenerative changes in tissue. Disorders in placental villi maturation and branching in gestosis were paralleled by hyperexpression of TSP-1 gene mRNA by placental cells and hyperexpression of TSP-1 protein predominating in the stromal elements of terminal villi and near villous vessels.

References

Dec 10, 2013·Bulletin of Experimental Biology and Medicine·Olga I StepanovaS A Sel'kov
Sep 3, 2011·Journal of Thrombosis and Haemostasis : JTH·P H AndraweeraScope Consortium
May 25, 2015·Archives of Medical Research·Dmitry Igorevich SokolovSergey A Selkov
Aug 9, 2019·Current Molecular Medicine·Dmitry Olegovich BazhenovDmitry Igorevich Sokolov

Citations

Jan 5, 1996·The Journal of Biological Chemistry·A G GaoW A Frazier
Feb 12, 1998·Annals of Internal Medicine·J LauC H Schmid
Apr 20, 2004·The International Journal of Biochemistry & Cell Biology·Jack Lawler, Michael Detmar
Mar 11, 2006·Clinical Science·Sally Chappell, Linda Morgan
Apr 7, 2007·Circulation Research·Izabela StaniszewskaCezary Marcinkiewicz
Dec 2, 2008·Bulletin of Experimental Biology and Medicine·D I SokolovSergey A Selkov

Related Concepts

MRNA Maturation
Abnormal Degeneration
Granzyme A Activity
Genes
Placenta Specimen
Placenta Disorders
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Stroma
Transcription, Genetic
Blood Vessel

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.