Expression of thrombospondin-1 gene mRNA and protein in the placenta in gestosis

Bulletin of Experimental Biology and Medicine
Yu V OstankovaD I Sokolov


The expression of TSP-1 gene mRNA and TSP-1 protein in the placental tissue was studied during normal pregnancy and in gestosis. The formation of placental tissue in normal gestation was associated with expression of TSP-1 gene mRNA and of TSP-1 protein. Gestosis was associated with inflammatory reaction in the placenta characterized by increased counts of lymphocytes and macrophages in the villous stroma and involution degenerative changes in tissue. Disorders in placental villi maturation and branching in gestosis were paralleled by hyperexpression of TSP-1 gene mRNA by placental cells and hyperexpression of TSP-1 protein predominating in the stromal elements of terminal villi and near villous vessels.


Dec 10, 2013·Bulletin of Experimental Biology and Medicine·Olga I StepanovaS A Sel'kov
Sep 3, 2011·Journal of Thrombosis and Haemostasis : JTH·P H AndraweeraScope Consortium
May 25, 2015·Archives of Medical Research·Dmitry Igorevich SokolovSergey A Selkov
Aug 9, 2019·Current Molecular Medicine·Dmitry Olegovich BazhenovDmitry Igorevich Sokolov


Jan 5, 1996·The Journal of Biological Chemistry·A G GaoW A Frazier
Feb 12, 1998·Annals of Internal Medicine·J LauC H Schmid
Apr 20, 2004·The International Journal of Biochemistry & Cell Biology·Jack Lawler, Michael Detmar
Mar 11, 2006·Clinical Science·Sally Chappell, Linda Morgan
Apr 7, 2007·Circulation Research·Izabela StaniszewskaCezary Marcinkiewicz
Dec 2, 2008·Bulletin of Experimental Biology and Medicine·D I SokolovSergey A Selkov

Related Concepts

MRNA Maturation
Abnormal Degeneration
Granzyme A Activity
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Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Transcription, Genetic
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