Expression of tissue inhibitor of metalloproteinases 1 and 2 is increased in fibrotic human liver

Gastroenterology
R C BenyonM J Arthur

Abstract

Tissue inhibitors of metalloproteinases may contribute to liver fibrosis by preventing remodeling of fibrillar collagens by interstitial collagenase. This hypothesis was investigated by comparing the relative expression of messenger RNA for interstitial collagenase, gelatinase A, and tissue inhibitor of metalloproteinases 1 and 2 in fibrotic and normal human liver. Hepatic expression of metalloproteinases and their inhibitors was examined using ribonuclease protection assay, immunocytochemistry, and immunoassay. Lipocyte expression of tissue inhibitors of metalloproteinases was examined using Northern blotting and reverse zymography. Messenger RNA levels for tissue inhibitors of metalloproteinase 1 and 2 were elevated to 260%-526% of levels in normal liver in biliary atresia, primary biliary cirrhosis, and primary sclerosing cholangitis. In fibrotic livers, tissue inhibitor of metalloproteinase 1 protein was 367%-724% of normal. Gelatinase A messenger RNA level increased to 324%-430% of normal values in fibrotic liver, but interstitial collagenase messenger RNA level was not significantly altered. Normal human liver lipocytes activated by culture on plastic expressed messenger RNA and protein for tissue inhibitor of metalloprot...Continue Reading

Citations

Jun 20, 2007·Pharmaceutical Research·Yuji Iimuro, David A Brenner
Jun 13, 2008·Clinical Reviews in Allergy & Immunology·Marco MarzioniAntonio Benedetti
Dec 14, 2011·Cellular & Molecular Immunology·Ruonan XuFu-Sheng Wang
Aug 14, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jennifer AltomonteOliver Ebert
Sep 8, 2011·Journal of Medicinal Food·Yu-Ting LoJane C-J Chao
Dec 25, 2007·Oligonucleotides·Zhaoyang YeRam I Mahato
Jun 1, 2012·QJM : Monthly Journal of the Association of Physicians·P Ramachandran, J P Iredale
Jun 17, 1999·Alcoholism, Clinical and Experimental Research·M J ArthurD A Mann
Jul 23, 1999·Annals of the New York Academy of Sciences·Y KatanoT Hayakawa
Jul 19, 2003·BMJ : British Medical Journal·John P Iredale
Oct 14, 2004·Gut·J Gillibert DuplantierJ Rosenbaum
Mar 15, 2000·Gut·R C Benyon, J P Iredale
Feb 26, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hiromitsu Hayashi, Takao Sakai
Mar 3, 2007·The Journal of Clinical Investigation·John P Iredale
Aug 1, 2007·Comparative Hepatology·Olav A GressnerAxel M Gressner
Jun 15, 2011·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Xiao-ning WangYi-yang Hu
Apr 17, 2013·Gastroenterology Research and Practice·Khanh Vinh Quốc L Ng, Lan Thi Hoàng Nguyễn
Oct 9, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lung-Yi LeeDavid P Foley
Sep 13, 2011·Scandinavian Journal of Gastroenterology·Timo RathReinhart Zachoval
Jul 23, 2014·Scandinavian Journal of Gastroenterology·Troels M BuskSøren Møller
May 30, 2014·International Journal of Molecular Sciences·Thomas TuNicholas A Shackel
Apr 22, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·H M El TayebiA I Abdelaziz
Dec 20, 2011·Pharmacological Reports : PR·Agnieszka Szuster-CiesielskaMartyna Kandefer-Szerszeń
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M YasudaS Ito
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M J BahrD A Mann
May 15, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C HellerbrandD A Brenner
Nov 28, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H YoshijiH Fukui
Jun 1, 2013·Surgical Pathology Clinics·Pierre BedossaDhanpat Jain
Jul 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N ThéretB Clément
Sep 25, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A M PréauxP Mavier
Sep 25, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R C BenyonM J Arthur
Jan 18, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Signe WieseSøren Møller
Jun 2, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Timo RathMartin Roderfeld
Apr 20, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Peter JarcuskaLubomír Skladaný
Oct 17, 2009·Journal of Ethnopharmacology·Jing-Hua WangChang-Gue Son
Apr 18, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A AltadillF J Vizoso

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