PMID: 8958780Nov 1, 1996Paper

Expression of tissue inhibitor of metalloproteinases-1 in the primate ovary during induced luteal regression

The Journal of Endocrinology
W C DuncanH M Fraser

Abstract

Although tissue inhibitor of metalloproteinases-1 (TIMP-1) is one of the major secretory products of the corpus luteum, the functional significance of this is not clear. In addition to its role as a specific inhibitor of the matrix metalloproteinase enzymes involved in tissue remodelling, it has recently been suggested that TIMP-1 is also a potent stimulator of steroidogenesis in vitro. However, in the ruminant, TIMP-1 expression increases during luteal regression. This study sought to determine (i) the effect of induced luteal regression on ovarian TIMP-1 expression in the primate and (ii) the expression of TIMP-1 in other steroidogenic and non-steroidogenic tissues. Marmoset ovaries were studied on day 10 of the normal luteal phase and 12 and 24 h after induced luteolysis, with either gonadotrophin-releasing hormone (GnRH) antagonist or prostaglandin F2 alpha analogue. Ovaries from different stages of the normal ovarian cycle were also studied. Expression of TIMP-1 was investigated by isotopic in situ hybridisation. TIMP-1 expression was also examined in a wide range of other marmoset tissues by Northern blotting and in situ hybridisation. TIMP-1 was found to be highly expressed in the marmoset corpus luteum. Luteolysis induc...Continue Reading

Citations

Mar 24, 2004·Critical Reviews in Oncology/hematology·Elise LambertEmmanuelle Petitfrère
Sep 30, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·Jacqueline A Maybin, W Colin Duncan
Sep 2, 2005·American Journal of Reproductive Immunology : AJRI·Hiroaki ShibaharaMitsuaki Suzuki
Apr 21, 2009·Biochimica Et Biophysica Acta·Cynthia TallantF Xavier Gomis-Rüth
Apr 25, 2001·Biology of Reproduction·T E Curry, K G Osteen
Mar 1, 2002·Biology of Reproduction·William A RickeMichael F Smith
Sep 19, 2002·Molecular Reproduction and Development·Qing-Lei LiCheng Zhu
Apr 6, 2006·Molecular Reproduction and Development·B PhanD Herr
Apr 30, 1999·Physiological Reviews·J A McCrackenJ C Lamsa

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