PMID: 11337816May 8, 2001Paper

Expression of titin in skeletal muscle varies with hind-limb unloading

Biological Research for Nursing
C E Kasper, L Xun

Abstract

The effects of prolonged hind-limb unloading on titin antibody localization and expression of titin isozymes of single fibers from the synergistic slow-twitch soleus (SOL) and fast-twitch plantaris (PLN) of adult rats were studied after 14 and 28 days of hind-limb unloading (HU). Titin antibody localization and expression was not altered at 14 days of HU. However, there was a 4% loss in antibody to Z-band distance (Ab-Z) in the SOL and an increase of 8% in PLN Ab-Z after 28 days of HU. The titin and myosin heavy chain composition of single fibers and small bundles of fibers from control and unloaded muscles were examined using 2% to 12% sodium dodecyl sulfate-polyacrylamide gel electrophoresis. There was a marked loss of relative amounts of titin in both SOL and PLN following 28 days of HU. As the protein loads for these measures were identical, the authors conclude that these findings represent an actual loss of titin density rather than a decreased value due to a loss of total muscle mass. Laser scanning densitometry of the titin bands show a marked decrease in density and molecular weight in unloaded SOL. In the PLN, marked losses of titin density were accompanied by decreased electrophoretic motility. The results demonstrat...Continue Reading

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Citations

Mar 28, 2012·Bulletin of Experimental Biology and Medicine·O M VeselovaI M Larina
Apr 4, 2009·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·V A KurushinB S Shenkman
Jul 16, 2013·Muscle & Nerve·Bao-Ting ZhangElla W Yeung
Apr 10, 2004·Nursing Outlook·Gayle Giboney Page
Sep 10, 2014·Biomechanics and Modeling in Mechanobiology·Katrina M WisdomEllen Kuhl
Jan 9, 2009·Journal of Muscle Research and Cell Motility·Boris S Shenkman, T L Nemirovskaya
Aug 3, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jacob M HausTodd A Trappe
Aug 17, 2005·Molecular Ecology·M RichardJ Clobert
Nov 7, 2019·Ecology and Evolution·Geoffrey M GouldJacqueline K Augustine
Sep 28, 2006·American Journal of Physiology. Endocrinology and Metabolism·T Maarit LehtiJyrki Komulainen
Oct 23, 2002·Journal of Applied Physiology·Katsumasa GotoToshitada Yoshioka
Mar 28, 2019·Frontiers in Physiology·Boris S Shenkman, Inessa B Kozlovskaya
Jan 8, 2021·Frontiers in Physiology·Liang-Ching TsaiLi-Qun Zhang

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