Expression of TLR4 and TLR9 mRNA in Lewis rats with experimental allergic neuritis

Neuroimmunomodulation
Yong-Ning Deng, Wen-Bin Zhou

Abstract

Experimental autoimmune neuritis (EAN) is a T cell-mediated animal model of the Guillain-Barré syndrome characterized by inflammation and demyelination of the peripheral nervous system (PNS). The key pathogenesis of EAN is the imbalance between Th1- and Th2-type immune response. Toll-like receptor (TLR) is a receptor of the innate immune system. It can recognize the antigen by pathogen-associated molecular patterns, and activate the antigen-presenting cells, producing costimulating molecules to activate T cells. In this study, we observed the expression of mRNA of TLR4 and TLR9 in EAN rats. Male Lewis rats were immunized with the component of PNS myelin sheath protein P0 180-199 (100 microg) and Freund's complete adjuvant (CFA). The clinical signs of rats and the pathological changes in the sciatic nerves were observed. The rats in the immunized group and the control group were sacrificed on day 7, 16, 24 and 33 after immunization. To observe the histopathological changes, sciatic nerve was embedded in paraffin, sectioned and stained with HE and Weil's stain. The mRNA expression of TLR4 and TLR9 in spleen, sciatic nerve, peripheral blood monocytes and lymph nodes was detected by reverse transcriptase PCR dynamically. The EAN gr...Continue Reading

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Citations

Dec 16, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Aditya SudhalkarBakulesh Khamar
Nov 10, 2011·Neuroimmunomodulation·Yu-Zhong WangHuan Yang
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Jan 24, 2015·Mediators of Inflammation·Kishan Kumar Nyati, Kashi Nath Prasad
Jan 31, 2020·Frontiers in Molecular Neuroscience·Chao ZhengTao Jin
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