Expression of TMEM207 in Colorectal Cancer: Relation between TMEM207 and Intelectin-1

Journal of Cancer
Kenichi MaedaTamotsu Takeuchi

Abstract

Recent research advances highlighted an intestinal goblet cell-produced lectin, intelectin-1 (also known as omentin-1), as a tumor suppressor. One study indicated that downregulation of intelectin-1 may be related to the unfavorable prognosis among patients with colorectal carcinoma at an advanced stage. The present study was aimed at analyzing the expression of a hitherto uncharacterized transmembrane protein TMEM207 in colorectal carcinoma, and we found that the TMEM207 function is linked to intelectin-1 processing. With specific antibodies, TMEM207 immunoreactivity was detected in 38 of 216 colorectal cancer tissue samples. TMEM207 immunoreactivity correlated inversely with lymph node metastatic status (p < 0.01). TMEM207 expression significantly correlated with the mucinous phenotype of colorectal carcinoma. A coimmunoprecipitation assay revealed an interaction between intelectin-1 and TMEM207 in colorectal cancer cells. A proximal ligation assay indicated that intelectin-1 and TMEM207 were colocalized to the cytoplasm of the colorectal cancer cells. A small-interfering-RNA-mediated knockdown of TMEM207 increased polyubiquitination and proteasome degradation of intelectin-1 in cultured colorectal cancer cells and decreased ...Continue Reading

Citations

Apr 20, 2017·International Journal of Molecular Sciences·Keisuke KawashimaTamotsu Takeuchi
Nov 23, 2017·Journal of Cellular and Molecular Medicine·Katsuaki BunaiTamotsu Takeuchi
Feb 23, 2019·PloS One·Ricardo LageIsabel Moscoso

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Methods Mentioned

BETA
electrophoresis
ELISA
coimmunoprecipitation
immunoprecipitation

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