Expression of TNF and the 55-kDa TNF receptor in epidermis, oral mucosa, lichen planus and squamous cell carcinoma

Oral Diseases
F YounesM Partridge

Abstract

TNF has diverse biological effects including a role in the immune response and growth regulatory effects. The aim of this study was to determine the nature and location of cells able to synthesise and respond to TNF in oral mucosa in health and disease. The location of immunoreactive TNF and 55-kDa and 75-kDa TNF receptors was demonstrated using immunohistology. We also used RT-PCR to help determine the sites of synthesis of this cytokine in oral mucosa. Only occasional TNF-positive cells were detected in normal epidermis and oral mucosa. However, this cytokine was found throughout the epithelia in oral lichen planus, leukoplakia and squamous cell carcinoma (SCC). The possible cellular sources and biological effects of TNF in these disease processes is discussed. The 55-kDa TNFR was expressed at the cell membrane throughout the epidermis, but confined to the lower cell layers on oral mucosa. Ten of 22 SCC did not express this receptor. A significant correlation was observed between the velocity of tumour growth and absence of TNF receptors. The growth inhibitory and immunoregulatory effects of TNF may be modulated by changes in receptor expression and alterations in synthesis of this cytokine in a subgroup of oral SCC.

References

Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E A CarswellB Williamson
Aug 1, 1992·The British Journal of Oral & Maxillofacial Surgery·J D Langdon, M Partridge
Nov 1, 1992·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·P M FarthingA T Cruchley
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·L J WalshG F Murphy
Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A H Enk, S I Katz
Mar 1, 1991·Journal of Dermatological Science·J N BarkerB J Nickoloff
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M BrockhausH Loetscher
Mar 1, 1990·British Journal of Cancer·G Semenzato
Oct 1, 1990·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·L J WalshG J Seymour
Oct 1, 1985·Oral Surgery, Oral Medicine, and Oral Pathology·J A RegeziJ T Headington
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M Fràter-SchröderP Böhlen
Apr 1, 1989·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·L A van LoonJ D Bos
May 1, 1989·Journal of Leukocyte Biology·J W LarrickT Shi

❮ Previous
Next ❯

Citations

May 7, 2002·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Mahmoud Rouabhia, Noëlla Deslauriers
Oct 30, 1999·Japanese Journal of Cancer Research : Gann·Y NakanoS Yagihashi
Feb 4, 2006·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Kobkan ThongprasomMantharop Chaimusig
Dec 18, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Rui LuGang Zhou
Oct 1, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Pattatheyil ArunCarter Van Waes
Feb 14, 2004·The Journal of Investigative Dermatology·Marco CarrozzoSergio Gandolfo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Avances en odontoestomatologia
J V BaganC Roig
Nederlands tijdschrift voor geneeskunde
T C Vriezen
Archivio stomatologico
F Gombos, R Serpico
Nederlands tijdschrift voor geneeskunde
W F de JongW A van der Kwast
© 2021 Meta ULC. All rights reserved