Expression of toll-like receptor 2 and plasma level of interleukin-10 are associated with outcome in tuberculosis.

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
J-Y WangL-N Lee

Abstract

Toll-like receptor (TLR) 2-mediated innate immunity is an important defense system against Mycobacterium tuberculosis infection. Studies on TLR2 protein expression and downstream cytokines in tuberculosis patients are lacking. TLR2 expression in the peripheral blood monocytes of 87 tuberculosis patients and 94 healthy subjects was evaluated using flow cytometry. TLR2 expression and its downstream cytokines, including interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-alpha, and interferon-gamma, were correlated with the clinical manifestations and outcomes of tuberculosis. The TLR2 expression in peripheral blood monocytes was higher in tuberculosis patients than in healthy subjects. Among the tuberculosis patients, those aged ≥70 years with disseminated tuberculosis or aged <70 years with symptom duration ≥14 days had lower initial TLR2 expression. After two months of treatment, TLR2 expression decreased in most patients, except in those whose sputum samples remained culture-positive for M. tuberculosis. Proportional hazards regression analyses revealed that high initial TLR2 expression and IL-10 plasma level were associated with shorter survival. TLR2 may play an important role in the course of tuberculosis. Its expression...Continue Reading

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Citations

Jun 1, 2016·International Journal of Mycobacteriology·Najeeha Talat IqbalGhaffar Dawood
Jun 25, 2013·Tropical Medicine & International Health : TM & IH·Najwa MhmoudW J Wendy van de Sande
Mar 24, 2015·Tuberculosis·Vanessa CliffordNigel Curtis
Aug 31, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chia-Chi LinYeong-Shiau Pu
Feb 20, 2018·Respirology : Official Journal of the Asian Pacific Society of Respirology·Delia GolettiTom H M Ottenhoff
Jul 19, 2017·Pathogens and Global Health·Majid Faridgohar, Hassan Nikoueinejad

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