Expression of toll-like receptors 2 and 4 in subplacental trophoblasts from guinea pigs (Cavia porcellus) following infection with Campylobacter jejuni

Veterinary Pathology
E R BurroughM J Yaeger

Abstract

Toll-like receptors 2 and 4 (TLR2 and TLR4) are well-characterized cell surface receptors that recognize specific pathogen-associated molecular patterns and play an important role in pathogen recognition and activation of the innate immune system. Variable expression of TLR2 and TLR4 has been described in trophoblasts from normal and diseased placentas; yet, there are limited data regarding trophoblast TLR expression in response to specific placental pathogens, and TLR expression in the guinea pig placenta has not been described. The guinea pig is an effective model for Campylobacter-induced abortion of small ruminants, and the authors have shown by immunohistochemistry that C jejuni localizes within syncytiotrophoblasts of the guinea pig subplacenta. The present study was designed to determine if the expression of either TLR2 or TLR4 would be affected in subplacental trophoblasts following infection with C jejuni. Immunohistochemistry for TLR2 and TLR4 was performed on placenta from guinea pigs that aborted following inoculation with C jejuni and from sham-inoculated controls. Quantitative assessment of TLR expression was performed, and mean immunoreactivity for TLR2 was significantly higher in subplacental trophoblasts from a...Continue Reading

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Citations

Dec 14, 2011·PloS One·Billy D NovosadMichelle C Callegan
Apr 19, 2011·Animal Reproduction Science·T R KannakiP C Verma
Nov 20, 2016·Annual Review of Animal Biosciences·Orhan SahinQijing Zhang
Oct 17, 2017·PloS One·Andrea G FernándezPablo C Baldi

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