Expression of TRAIL, DR4, and DR5 in kidney and serum from patients receiving renal transplantation

Transplantation Proceedings
C J SongB Q Jin

Abstract

Renal transplantation is the best treatment of some end-stage renal diseases. Unfortunately, not every transplant is successful due to the rejection or dysfunction of the transplanted kidney. Many cytokines participate in rejection by inducing inflammation or apoptosis. In this study, the expressions of TRAIL, DR4, and DR5 in rejected renal tissue and of serum soluble TRAIL (sTRAIL) in patients with kidney rejection were investigated by immunohistochemical staining and sandwich enzyme-linked immunosorbent assay, respectively. The results showed that the expression of TRAIL, DR4 and DR5, and serum sTRAIL levels were markedly upregulated among renal transplant patients. Since both membrane and soluble forms of TRAIL can induce apoptosis of DR4/DR5-expressing cells via recruiting FADD and caspase 8, elevated TRAIL and its receptors may participate in renal graft rejection.

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Citations

Apr 8, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Vinh NguyenVioleta Rus
Apr 18, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Jing-Mei LiuBo-Quan Jin
Oct 24, 2013·International Journal of Cardiology·Antonella GaleoneMaria Grano
Jul 16, 2016·Biomedit︠s︡inskai︠a︡ khimii︠a︡·Y S KimA Yu Lupatov
Nov 20, 2013·Current Opinion in Nephrology and Hypertension·Riccardo Candido
Mar 23, 2012·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Ignacio J Sánchez-LázaroAntonio Salvador-Sanz
Jun 24, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Qian ChenXiaochun Wan

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