Sep 2, 2005

Expression of transforming growth factor and basic fibroblast growth factor and core protein of proteoglycan in human vertebral cartilaginous endplate of adolescent idiopathic scoliosis

Spine
Hongguang XuXinyu Yang

Abstract

To compare the expression of cytokines and core protein of proteoglycan in the scoliotic concave and convex cartilaginous endplate using immunohistochemical staining. To define the possible role of transforming growth factor beta 1 (TGFbeta1), basic fibroblast growth factor (bFGF), and core protein of proteoglycan in the development of adolescent idiopathic scoliosis. Changes in the endplate composition have been implicated as possible etiologic factors in the pathogenesis of adolescent idiopathic scoliosis. Cytokines have exclusive effects on cartilage. Thus comparing the expression of the cytokines and matrix on the convex and concave sides of scoliotic endplate tissues may help to understand the role of endplate tissues in the induction and/or progression of idiopathic scoliosis. The convex and concave half of cartilage endplate was collected at the apex and end vertebrae from 12 patients. The expression of TGFbeta1, bFGF, and core protein on both sides was examined with the immunohistochemistry method, and results were analyzed with the image analysis system. TGFbeta1, bFGF, and core protein of proteoglycan were all expressed in the cytoplasm of chondrocytes in the cartilaginous endplate. The area density and quantity densi...Continue Reading

Mentioned in this Paper

Recombinant Transforming Growth Factor
Scoliosis, Idiopathic, Susceptibility TO, 1 (Finding)
Pathogenic Aspects
Scoliosis, Unspecified
Chondroitin Sulfate Proteoglycans
Transforming Growth Factor beta
Adolescent Idiopathic Scoliosis
Pathogenesis
Immunohistochemistry
TGFB1 protein, human

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