Expression of transforming growth factor beta in the embryonic avian lens coincides with the presence of mitochondria

Developmental Dynamics : an Official Publication of the American Association of Anatomists
J D PottsD C Beebe

Abstract

During their maturation, lens cells lose all membrane bound organelles, including mitochondria. In chicken embryos this process begins in the central lens fibers beginning around embryonic day 12 (E12). Transforming growth factor beta (TGF beta) is a multipotent growth modulator thought to play a role in numerous developmental processes. TGF beta 1 has been localized to mitochondria in rat liver cells and muscle cells. In the present study, we examined the expression of TGF beta isoform mRNAs and proteins during chicken embryonic lens development. PCR analysis demonstrated TGF beta 2 and TGF beta 3 transcripts in the lens epithelium and fibers throughout pre- and post-hatching development. TGF beta isoforms were detected throughout the lens epithelium and fibers early in development (E6). However by E19, the distribution of TGF beta 2 and TGF beta 3 transcripts and proteins coincided with regions of the lens that contained mitochondria. In addition, intense TGF beta staining was observed in the basal portions of the equatorial epithelial cells, a region with abundant mitochondria. Transcripts for TGF beta 1 and TGF beta 4 were not detected in any tissue or time frame examined. Similarly, no immunostaining for TGF beta 1 was obs...Continue Reading

References

Jun 1, 1992·Developmental Dynamics : an Official Publication of the American Association of Anatomists·S Bassnett, D C Beebe
Feb 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J D PottsR B Runyan
Jan 1, 1990·Annual Review of Cell Biology·J Massagué
Oct 1, 1990·Current Eye Research·H D JampelA B Roberts
Dec 1, 1989·The Journal of Cell Biology·A J RidleyH Land
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J MassaguéB Nadal-Ginard
Sep 12, 1988·Nucleic Acids Research·S B JakowlewA B Roberts
Jan 1, 1994·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J V BarnettR L Maas
Sep 1, 1993·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J D Potts, J L Carrington
Oct 1, 1993·Current Eye Research·U Schlötzer-Schrehardt, S Dörfler

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Citations

Dec 1, 1996·Differentiation; Research in Biological Diversity·M A Wride
Nov 26, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S Roth-EichhornA M Gressner
Jul 9, 1999·Muscle & Nerve·N MurakamiG Hammond-Tooke
Dec 22, 2004·Progress in Retinal and Eye Research·T Stupp, S Thanos

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