PMID: 11340559May 8, 2001Paper

Expression of transforming growth factor beta(1), beta(3), and basic fibroblast growth factor in full-thickness skin wounds of equine limbs and thorax

Veterinary Surgery : VS
C L TheoretJohn R Gordon

Abstract

To map the expression of transforming growth factor (TGF)-beta(1), TGF-beta(3), and basic fibroblast growth factor (bFGF) in full-thickness skin wounds of the horse. To determine whether their expression differs between limbs and thorax, to understand the pathogenesis of exuberant granulation tissue. Six wounds were created on one lateral metacarpal area and one midthoracic area of each horse. Sequential wound biopsies allowed comparison of the temporal expression of growth factors between limb and thoracic wounds. Four 2- to 4-year-old horses. Wounds were assessed grossly and histologically at 12 and 24 hours, and 2, 5, 10, and 14 days postoperatively. ELISAs were used to measure the growth factor concentrations of homogenates of wound biopsies taken at the same timepoints. TGF-beta(1) peaked at 24 hours in both locations and returned to baseline in thoracic wounds by 14 days but remained elevated in limb wounds for the duration of the study. Expression kinetics of TGF-beta(3) differed from those of TGF-beta(1). TGF-beta(3) concentrations gradually increased over time, showing a trend toward an earlier and higher peak in thoracic compared with limb wounds. bFGF expression kinetics resembled those of TGF-beta(1), but no statist...Continue Reading

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Citations

Aug 23, 2005·American Journal of Veterinary Research·Marilys Ducharme-DesjarlaisChristine L Theoret
Jan 24, 2009·Equine Veterinary Journal·V MiragliottaC L Theoret
Aug 29, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Gerco BoschP René van Weeren
Feb 1, 2013·American Journal of Veterinary Research·Kaitlyn A LinkBrandon N Lillie
Apr 15, 2014·Lasers in Medical Science·Gabriela Bortolança ChiarottoFernanda Aparecida Sampaio Mendonça
Apr 4, 2017·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Rebecca M HarmanGerlinde R Van de Walle
Jan 15, 2005·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·John R MiklerJerry C High
Jul 9, 2002·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Robin van den BoomMark W J Ferguson
Aug 2, 2006·Journal of Veterinary Dentistry·James L CarmaltAndrew L Allen
Sep 24, 2005·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Elodie LepaultChristine L Theoret
Jan 6, 2009·Veterinary Dermatology·Vincenzo MiragliottaChristine L Theoret
Oct 19, 2016·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Christa J BodaanChristine Theoret
Jul 5, 2003·Physiological Reviews·Sabine Werner, Richard Grose
Nov 16, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Lauren V SchnabelLisa A Fortier
Oct 14, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Nicholas W ClavinBabak J Mehrara
Oct 20, 2010·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Christophe J CelesteChristine L Theoret
Mar 3, 2011·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Karine DescheneChristine L Theoret
Sep 12, 2015·New Zealand Veterinary Journal·C L TheoretC B Riley
Feb 20, 2003·International Journal of Legal Medicine·Masataka TakamiyaYasuhiro Aoki
Sep 11, 2013·Veterinary Surgery : VS·Christine L TheoretJohn Hicks
Dec 23, 2017·Frontiers in Veterinary Science·Kathryn A SeabaughSteeve Giguère
Apr 13, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Shelley S PollyLinda A Dahlgren
Dec 14, 2019·Advances in Wound Care·Dorothy M Supp
Feb 28, 2013·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Christine L Theoret, Jacintha M Wilmink
Jun 5, 2003·Experimental and Molecular Pathology·Charleata A CarterCynthia J M Kane

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