Expression of transforming growth factor beta1, beta2, and beta3 in chronic, cancer-associated, obstructive pancreatitis.

Archives of Pathology & Laboratory Medicine
Yuki FukumuraKoichi Suda

Abstract

Myofibroblasts are considered to play central roles in pancreatic fibrosis. The potent fibrogenic capacities of transforming growth factor betas (TGF-betas) have been emphasized in vitro and in animal studies. However, the roles of TGF-betas in human chronic pancreatitis have not been fully clarified. To investigate whether expressions of TGF-betas are related to myofibroblast distribution in chronic, cancer-associated, obstructive pancreatitis (COP). Histopathologic studies using hematoxylin-eosin and Elastica-Masson trichrome and immunohistochemical studies using antibodies against alpha-smooth muscle actin (SMA); CD68; TGF-beta1, -beta2, and -beta3; and TGF-beta soluble receptor type II were performed in 19 COP cases and 6 controls. By classifying COP tissues into 3 fibrosis phases by the amount of collagen deposits, immunoreactivities for TGF-betas, histopathologic changes, and myofibroblast distribution were examined for each fibrosis phase. Six cases were categorized in the early stage of fibrosis, 8 in the intermediate stage, and 5 in the advanced stage. Immunoreactivities for all 3 isoforms of TGF-beta were observed in occasional myofibroblasts. In the early and intermediate stages, TGF-beta1-expressing macrophages and ...Continue Reading

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Citations

Aug 4, 2007·American Journal of Respiratory Cell and Molecular Biology·Yasushi ShintaniMargaret J Wheelock
Apr 7, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Xufeng TaoGary Guishan Xiao
Jul 22, 2008·The Journal of Surgical Research·Buckminster FarrowDavid H Berger
May 8, 2008·The American Journal of Surgical Pathology·Sönke DetlefsenGünter Klöppel
Jun 19, 2010·Cell Biology International·Paola Moreno-AlvarezMarina Macías-Silva
Jan 1, 2011·Cancers·Debashis Nandy, Debabrata Mukhopadhyay

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