Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease

Gastroenterology
M W BabyatskyD K Podolsky

Abstract

Transforming growth factors (TGFs) alpha and beta are key regulatory peptides that modulate mucosal cell populations critical to inflammatory bowel disease. The aim of this study was to assess TGF-alpha and TGF-beta expression in human colonic mucosa. TGF-alpha and TGF-beta expression was assessed in colonic mucosa from patients with ulcerative colitis, patients with Crohn's disease, and controls by Northern blot analysis, in situ hybridization, and bioassay. TGF-alpha messenger RNA expression localized to the villous tips of the small intestine and the surface epithelium of the colon. TGF-alpha expression was enhanced 2.3-fold in inactive ulcerative colitis mucosa relative to active ulcerative colitis, Crohn's disease, or normal controls. Enhanced expression correlated with duration of disease. TGF-beta expression was increased in affected mucosa from both patients with ulcerative colitis and Crohn's disease with active disease. TGF-beta1 messenger RNA expression in ulcerative colitis and Crohn's disease localized mostly to cells of the lamina propria with the highest concentration in inflammatory cells closest to the luminal surface. TGF-alpha may contribute to epithelial hyperproliferation and the increased risk of malignanc...Continue Reading

Citations

Jan 1, 1997·Springer Seminars in Immunopathology·P BrandtzaegJ Rugtveit
Nov 17, 1998·The Journal of Experimental Medicine·M BoirivantW Strober
Aug 13, 1999·The American Journal of Physiology·D W PowellA B West
Jun 22, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C J XianL C Read
Nov 3, 2001·European Journal of Gastroenterology & Hepatology·M Steinkamp, M Reinshagen
Aug 16, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·James G SimmonsP Kay Lund
Sep 12, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jorge M UribeKim E Barrett
Jul 25, 2003·The New England Journal of Medicine·Richard J Farrell
Apr 3, 2004·Inflammatory Bowel Diseases·Gert Van AsschePaul Rutgeerts
Oct 9, 2004·Inflammatory Bowel Diseases·Dov WengrowerEran Goldin
Mar 22, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Bruce A VallanceStephen M Collins
Apr 9, 2005·Gene Therapy·I CastagliuoloG Palù
Mar 15, 2006·World Journal of Gastroenterology : WJG·Giuliana ZanninelliGiovanni Latella
Jan 30, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Apichart NanakinTsutomu Chiba
Feb 13, 2007·Immunological Reviews·Dina Montufar-SolisJohn R Klein
Sep 7, 2007·Annals of the New York Academy of Sciences·Malin JohanssonSture Forsgren
May 2, 2008·The Journal of Pharmacology and Experimental Therapeutics·Yujiro HayashiSunao Kawano
Oct 8, 2009·Immunology·Anja A KühlJörg C Hoffmann
Feb 13, 2009·Allergy·L Saurer, C Mueller
Apr 30, 2013·Gut·Florian RiederWilliam J Sandborn
Mar 30, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Dimitrios C ZiogasEfi Kokkotou
Jun 14, 2013·Bulletin of Mathematical Biology·Wing-Cheong LoAvner Friedman
Jan 28, 2014·Journal of Crohn's & Colitis·Sharyle A FowlerVijay Yajnik
Apr 30, 2017·Journal of Crohn's & Colitis·Christopher A LambJohn A Kirby
Jun 6, 2017·The British Journal of Dermatology·D Di FuscoG Monteleone
Sep 5, 2017·Oncogene·P ChandrasingheJ Warusavitarne
Jun 20, 2018·BMC Immunology·Milad Sabzevary-GhahfarokhiEhsan Razmara
Apr 16, 2019·Frontiers in Pharmacology·Davide Di FuscoGiovanni Monteleone
Feb 24, 1999·Inflammatory Bowel Diseases·P L Beck, D K Podolsky
Apr 8, 1998·The American Journal of Physiology·M A MeijssenD K Podolsky
Jul 31, 1998·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M KedingerP Simon-Assmann
Aug 13, 1999·The American Journal of Physiology·J BeltingerY R Mahida
May 25, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C V WhitingP W Bland
Sep 1, 1999·Journal of Pediatric Gastroenterology and Nutrition·P LionettiA Vierucci
Oct 22, 2002·American Journal of Physiology. Cell Physiology·Kathryn HoweDerek M McKay

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.