Expression of transforming growth factors beta-1, beta 2 and beta 3 in human bladder carcinomas

British Journal of Cancer
I E EderH Klocker

Abstract

We previously detected elevated transforming growth factor beta-1 (TGF-beta1) serum levels in patients with invasive bladder carcinomas. In this study, we therefore investigated whether elevated serum levels correlate with enhanced TGF-beta expression in human bladder tumours. mRNA levels of TGF-beta1, -beta2 and -beta3 were reduced in bladder tumour tissue to 86%, 68% and 56%, respectively, of the levels in normal urothelium. On the other hand, TGF-beta1 protein levels were found to be higher in superficial tumours (Ta-T1) (mean level of 0.153 ng mg(-1)) and in invasive T2/T3 tumours (mean level of 0.104 ng mg(-1)) compared with normal urothelium (mean level of 0.065 ng mg(-1)). Invasive T4 tumours, however, contained only low amounts of TGF-beta1 (mean level of 0.02 ng mg(-1)). Neither in mean nor in individual patients were serum and tissue TGF-beta levels correlated with each other. Cell culture experiments on primary bladder cells revealed a 57% decrease in TGF-beta1 mRNA levels in tumour compared with normal epithelial cells. Tumour epithelial cells contained about two times higher levels of TGF-beta2 and TGF-beta3 mRNA than normal epithelial cells. Fibroblasts expressed about the same amount of TGF-beta1 or TGF-beta2 as ...Continue Reading

Citations

Dec 18, 2019·Cells·Joanna BoguslawskaAgnieszka Piekielko-Witkowska
Apr 13, 2011·PloS One·Apostolos ZaravinosDemetrios A Spandidos
Jan 23, 2014·World Journal of Urology·Marina DegoricijaJanoš Terzić
Dec 14, 1999·The American Journal of Pathology·M V CronauerF A Offner
Dec 28, 1999·Microbes and Infection·M Reiss
Jul 27, 2010·Molecular and Cellular Endocrinology·R K IlesS A Butler

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